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Using surveillance data to determine treatment rates and outcomes for patients with chronic hepatitis C virus infection

The aim of this work was to develop and validate an algorithm to monitor rates of, and response to, treatment of patients infected with hepatitis C virus (HCV) across England using routine laboratory HCV RNA testing data. HCV testing activity between January 2002 and December 2011 was extracted from...

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Autores principales: Lattimore, Sam, Irving, Will, Collins, Sarah, Penman, Celia, Ramsay, Mary, on Behalf of the Collaboration for the Sentinel Surveillance of Blood-Borne Virus Testing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258076/
https://www.ncbi.nlm.nih.gov/pubmed/24214920
http://dx.doi.org/10.1002/hep.26926
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author Lattimore, Sam
Irving, Will
Collins, Sarah
Penman, Celia
Ramsay, Mary
on Behalf of the Collaboration for the Sentinel Surveillance of Blood-Borne Virus Testing,
author_facet Lattimore, Sam
Irving, Will
Collins, Sarah
Penman, Celia
Ramsay, Mary
on Behalf of the Collaboration for the Sentinel Surveillance of Blood-Borne Virus Testing,
author_sort Lattimore, Sam
collection PubMed
description The aim of this work was to develop and validate an algorithm to monitor rates of, and response to, treatment of patients infected with hepatitis C virus (HCV) across England using routine laboratory HCV RNA testing data. HCV testing activity between January 2002 and December 2011 was extracted from the local laboratory information systems of a sentinel network of 23 laboratories across England. An algorithm based on frequency of HCV RNA testing within a defined time period was designed to identify treated patients. Validation of the algorithm was undertaken for one center by comparison with treatment data recorded in a clinical database managed by the Trent HCV Study Group. In total, 267,887 HCV RNA test results from 100,640 individuals were extracted. Of these, 78.9% (79,360) tested positive for viral RNA, indicating an active infection, 20.8% (16,538) of whom had a repeat pattern of HCV RNA testing suggestive of treatment monitoring. Annual numbers of individuals treated increased rapidly from 468 in 2002 to 3,295 in 2009, but decreased to 3,110 in 2010. Approximately two thirds (63.3%; 10,468) of those treated had results consistent with a sustained virological response, including 55.3% and 67.1% of those with a genotype 1 and non-1 virus, respectively. Validation against the Trent clinical database demonstrated that the algorithm was 95% sensitive and 93% specific in detecting treatment and 100% sensitive and 93% specific for detecting treatment outcome. Conclusions: Laboratory testing activity, collected through a sentinel surveillance program, has enabled the first country-wide analysis of treatment and response among HCV-infected individuals. Our approach provides a sensitive, robust, and sustainable method for monitoring service provision across England. (Hepatology 2014;59:1343-1350)
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spelling pubmed-42580762014-12-11 Using surveillance data to determine treatment rates and outcomes for patients with chronic hepatitis C virus infection Lattimore, Sam Irving, Will Collins, Sarah Penman, Celia Ramsay, Mary on Behalf of the Collaboration for the Sentinel Surveillance of Blood-Borne Virus Testing, Hepatology Viral Hepatitis The aim of this work was to develop and validate an algorithm to monitor rates of, and response to, treatment of patients infected with hepatitis C virus (HCV) across England using routine laboratory HCV RNA testing data. HCV testing activity between January 2002 and December 2011 was extracted from the local laboratory information systems of a sentinel network of 23 laboratories across England. An algorithm based on frequency of HCV RNA testing within a defined time period was designed to identify treated patients. Validation of the algorithm was undertaken for one center by comparison with treatment data recorded in a clinical database managed by the Trent HCV Study Group. In total, 267,887 HCV RNA test results from 100,640 individuals were extracted. Of these, 78.9% (79,360) tested positive for viral RNA, indicating an active infection, 20.8% (16,538) of whom had a repeat pattern of HCV RNA testing suggestive of treatment monitoring. Annual numbers of individuals treated increased rapidly from 468 in 2002 to 3,295 in 2009, but decreased to 3,110 in 2010. Approximately two thirds (63.3%; 10,468) of those treated had results consistent with a sustained virological response, including 55.3% and 67.1% of those with a genotype 1 and non-1 virus, respectively. Validation against the Trent clinical database demonstrated that the algorithm was 95% sensitive and 93% specific in detecting treatment and 100% sensitive and 93% specific for detecting treatment outcome. Conclusions: Laboratory testing activity, collected through a sentinel surveillance program, has enabled the first country-wide analysis of treatment and response among HCV-infected individuals. Our approach provides a sensitive, robust, and sustainable method for monitoring service provision across England. (Hepatology 2014;59:1343-1350) BlackWell Publishing Ltd 2014-04 2014-02-28 /pmc/articles/PMC4258076/ /pubmed/24214920 http://dx.doi.org/10.1002/hep.26926 Text en Copyright © 2013 The Authors. Hepatology published by Wiley on behalf of the American Association for the Study of Liver Diseases. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Viral Hepatitis
Lattimore, Sam
Irving, Will
Collins, Sarah
Penman, Celia
Ramsay, Mary
on Behalf of the Collaboration for the Sentinel Surveillance of Blood-Borne Virus Testing,
Using surveillance data to determine treatment rates and outcomes for patients with chronic hepatitis C virus infection
title Using surveillance data to determine treatment rates and outcomes for patients with chronic hepatitis C virus infection
title_full Using surveillance data to determine treatment rates and outcomes for patients with chronic hepatitis C virus infection
title_fullStr Using surveillance data to determine treatment rates and outcomes for patients with chronic hepatitis C virus infection
title_full_unstemmed Using surveillance data to determine treatment rates and outcomes for patients with chronic hepatitis C virus infection
title_short Using surveillance data to determine treatment rates and outcomes for patients with chronic hepatitis C virus infection
title_sort using surveillance data to determine treatment rates and outcomes for patients with chronic hepatitis c virus infection
topic Viral Hepatitis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258076/
https://www.ncbi.nlm.nih.gov/pubmed/24214920
http://dx.doi.org/10.1002/hep.26926
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