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The Role of the Hippocampus in Passive and Active Spatial Learning

Rats with lesions of the hippocampus or sham lesions were required in four experiments to escape from a square swimming pool by finding a submerged platform. Experiments 1 and 2 commenced with passive training in which rats were repeatedly placed on the platform in one corner—the correct corner—of a...

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Autores principales: Kosaki, Yutaka, Lin, Tzu-Ching Esther, Horne, Murray R, Pearce, John M, Gilroy, Kerry E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258078/
https://www.ncbi.nlm.nih.gov/pubmed/25131441
http://dx.doi.org/10.1002/hipo.22343
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author Kosaki, Yutaka
Lin, Tzu-Ching Esther
Horne, Murray R
Pearce, John M
Gilroy, Kerry E
author_facet Kosaki, Yutaka
Lin, Tzu-Ching Esther
Horne, Murray R
Pearce, John M
Gilroy, Kerry E
author_sort Kosaki, Yutaka
collection PubMed
description Rats with lesions of the hippocampus or sham lesions were required in four experiments to escape from a square swimming pool by finding a submerged platform. Experiments 1 and 2 commenced with passive training in which rats were repeatedly placed on the platform in one corner—the correct corner—of a pool with distinctive walls. A test trial then revealed a strong preference for the correct corner in the sham but not the hippocampal group. Subsequent active training of being required to swim to the platform resulted in both groups acquiring a preference for the correct corner in the two experiments. In Experiments 3 and 4, rats were required to solve a discrimination between different panels pasted to the walls of the pool, by swimming to the middle of a correct panel. Hippocampal lesions prevented a discrimination being formed between panels of different lengths (Experiment 3), but not between panels showing lines of different orientations (Experiment 4); rats with sham lesions mastered both problems. It is suggested that an intact hippocampus is necessary for the formation of stimulus-goal associations that permit successful passive spatial leaning. It is further suggested that an intact hippocampus is not necessary for the formation of stimulus-response associations, except when they involve information about length or distance. © 2014 The Authors. Hippocampus Published by Wiley Periodicals, Inc.
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spelling pubmed-42580782014-12-11 The Role of the Hippocampus in Passive and Active Spatial Learning Kosaki, Yutaka Lin, Tzu-Ching Esther Horne, Murray R Pearce, John M Gilroy, Kerry E Hippocampus Research Articles Rats with lesions of the hippocampus or sham lesions were required in four experiments to escape from a square swimming pool by finding a submerged platform. Experiments 1 and 2 commenced with passive training in which rats were repeatedly placed on the platform in one corner—the correct corner—of a pool with distinctive walls. A test trial then revealed a strong preference for the correct corner in the sham but not the hippocampal group. Subsequent active training of being required to swim to the platform resulted in both groups acquiring a preference for the correct corner in the two experiments. In Experiments 3 and 4, rats were required to solve a discrimination between different panels pasted to the walls of the pool, by swimming to the middle of a correct panel. Hippocampal lesions prevented a discrimination being formed between panels of different lengths (Experiment 3), but not between panels showing lines of different orientations (Experiment 4); rats with sham lesions mastered both problems. It is suggested that an intact hippocampus is necessary for the formation of stimulus-goal associations that permit successful passive spatial leaning. It is further suggested that an intact hippocampus is not necessary for the formation of stimulus-response associations, except when they involve information about length or distance. © 2014 The Authors. Hippocampus Published by Wiley Periodicals, Inc. BlackWell Publishing Ltd 2014-12 2014-08-28 /pmc/articles/PMC4258078/ /pubmed/25131441 http://dx.doi.org/10.1002/hipo.22343 Text en © 2014 The Authors. Hippocampus Published by Wiley Periodicals, Inc. http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Kosaki, Yutaka
Lin, Tzu-Ching Esther
Horne, Murray R
Pearce, John M
Gilroy, Kerry E
The Role of the Hippocampus in Passive and Active Spatial Learning
title The Role of the Hippocampus in Passive and Active Spatial Learning
title_full The Role of the Hippocampus in Passive and Active Spatial Learning
title_fullStr The Role of the Hippocampus in Passive and Active Spatial Learning
title_full_unstemmed The Role of the Hippocampus in Passive and Active Spatial Learning
title_short The Role of the Hippocampus in Passive and Active Spatial Learning
title_sort role of the hippocampus in passive and active spatial learning
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258078/
https://www.ncbi.nlm.nih.gov/pubmed/25131441
http://dx.doi.org/10.1002/hipo.22343
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