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Antifungal Activity of Decyl Gallate against Several Species of Pathogenic Fungi

This work aims to demonstrate that the gallic acid structure modification to the decyl gallate (G14) compound contributed to increase the antifungal activity against several species of pathogenic fungi, mainly, Candida spp., Cryptococcus spp., Paracoccidioides spp., and Histoplasma capsulatum, accor...

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Detalles Bibliográficos
Autores principales: de Paula e Silva, Ana Carolina Alves, Costa-Orlandi, Caroline Barcelos, Gullo, Fernanda Patrícia, Sangalli-Leite, Fernanda, de Oliveira, Haroldo Cesar, da Silva, Julhiany de Fátima, Scorzoni, Liliana, Pitangui, Nayla de Souza, Rossi, Suélen Andrea, Benaducci, Tatiane, Wolf, Vanessa Gonçalves, Regasini, Luis Octávio, Petrônio, Maicon Segalla, Silva, Dulce Helena Siqueira, Bolzani, Vanderlan S., Fusco-Almeida, Ana Marisa, Mendes-Giannini, Maria José Soares
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258339/
https://www.ncbi.nlm.nih.gov/pubmed/25505923
http://dx.doi.org/10.1155/2014/506273
Descripción
Sumario:This work aims to demonstrate that the gallic acid structure modification to the decyl gallate (G14) compound contributed to increase the antifungal activity against several species of pathogenic fungi, mainly, Candida spp., Cryptococcus spp., Paracoccidioides spp., and Histoplasma capsulatum, according to standardized microdilution method described by Clinical Laboratory Standard Institute (CLSI) documents. Moreover this compound has a particularly good selectivity index value, which makes it an excellent candidate for broad-spectrum antifungal prototype and encourages the continuation of subsequent studies for the discovery of its mechanism of action.