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Liver Fibrosis and Protection Mechanisms Action of Medicinal Plants Targeting Apoptosis of Hepatocytes and Hepatic Stellate Cells

Following chronic liver injury, hepatocytes undergo apoptosis leading to activation of hepatic stellate cells (HSC). Consequently, activated HSC proliferate and produce excessive extracellular matrix, responsible for the scar formation. The pandemic trend of obesity, combined with the high incidence...

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Detalles Bibliográficos
Autores principales: Duval, Florent, Moreno-Cuevas, Jorge E., González-Garza, Maria Teresa, Rodríguez-Montalvo, Carlos, Cruz-Vega, Delia Elva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258378/
https://www.ncbi.nlm.nih.gov/pubmed/25505905
http://dx.doi.org/10.1155/2014/373295
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author Duval, Florent
Moreno-Cuevas, Jorge E.
González-Garza, Maria Teresa
Rodríguez-Montalvo, Carlos
Cruz-Vega, Delia Elva
author_facet Duval, Florent
Moreno-Cuevas, Jorge E.
González-Garza, Maria Teresa
Rodríguez-Montalvo, Carlos
Cruz-Vega, Delia Elva
author_sort Duval, Florent
collection PubMed
description Following chronic liver injury, hepatocytes undergo apoptosis leading to activation of hepatic stellate cells (HSC). Consequently, activated HSC proliferate and produce excessive extracellular matrix, responsible for the scar formation. The pandemic trend of obesity, combined with the high incidence of alcohol intake and viral hepatitis infections, highlights the urgent need to find accessible antifibrotic therapies. Treatment strategies should take into account the versatility of its pathogenesis and act on all the cell lines involved to reduce liver fibrosis. Medicinal plants are achieving popularity as antifibrotic agents, supported by their safety, cost-effectiveness, and versatility. This review will describe the role of hepatocytes and HSC in the pathogenesis of liver fibrosis and detail the mechanisms of modulation of apoptosis of both cell lines by twelve known hepatoprotective plants in order to reduce liver fibrosis.
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spelling pubmed-42583782014-12-11 Liver Fibrosis and Protection Mechanisms Action of Medicinal Plants Targeting Apoptosis of Hepatocytes and Hepatic Stellate Cells Duval, Florent Moreno-Cuevas, Jorge E. González-Garza, Maria Teresa Rodríguez-Montalvo, Carlos Cruz-Vega, Delia Elva Adv Pharmacol Sci Review Article Following chronic liver injury, hepatocytes undergo apoptosis leading to activation of hepatic stellate cells (HSC). Consequently, activated HSC proliferate and produce excessive extracellular matrix, responsible for the scar formation. The pandemic trend of obesity, combined with the high incidence of alcohol intake and viral hepatitis infections, highlights the urgent need to find accessible antifibrotic therapies. Treatment strategies should take into account the versatility of its pathogenesis and act on all the cell lines involved to reduce liver fibrosis. Medicinal plants are achieving popularity as antifibrotic agents, supported by their safety, cost-effectiveness, and versatility. This review will describe the role of hepatocytes and HSC in the pathogenesis of liver fibrosis and detail the mechanisms of modulation of apoptosis of both cell lines by twelve known hepatoprotective plants in order to reduce liver fibrosis. Hindawi Publishing Corporation 2014 2014-11-20 /pmc/articles/PMC4258378/ /pubmed/25505905 http://dx.doi.org/10.1155/2014/373295 Text en Copyright © 2014 Florent Duval et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Duval, Florent
Moreno-Cuevas, Jorge E.
González-Garza, Maria Teresa
Rodríguez-Montalvo, Carlos
Cruz-Vega, Delia Elva
Liver Fibrosis and Protection Mechanisms Action of Medicinal Plants Targeting Apoptosis of Hepatocytes and Hepatic Stellate Cells
title Liver Fibrosis and Protection Mechanisms Action of Medicinal Plants Targeting Apoptosis of Hepatocytes and Hepatic Stellate Cells
title_full Liver Fibrosis and Protection Mechanisms Action of Medicinal Plants Targeting Apoptosis of Hepatocytes and Hepatic Stellate Cells
title_fullStr Liver Fibrosis and Protection Mechanisms Action of Medicinal Plants Targeting Apoptosis of Hepatocytes and Hepatic Stellate Cells
title_full_unstemmed Liver Fibrosis and Protection Mechanisms Action of Medicinal Plants Targeting Apoptosis of Hepatocytes and Hepatic Stellate Cells
title_short Liver Fibrosis and Protection Mechanisms Action of Medicinal Plants Targeting Apoptosis of Hepatocytes and Hepatic Stellate Cells
title_sort liver fibrosis and protection mechanisms action of medicinal plants targeting apoptosis of hepatocytes and hepatic stellate cells
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258378/
https://www.ncbi.nlm.nih.gov/pubmed/25505905
http://dx.doi.org/10.1155/2014/373295
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