Cargando…

Enantiomer-selective pharmacokinetics, oral bioavailability, and sex effects of various alpha-lipoic acid dosage forms

The present study aimed to examine the enantiomer-selective pharmacokinetics (PK), relative bioavailability (F(rel)), and sex effects of various oral dosage forms of racemic alpha-lipoic acid (ALA). In an open-label, randomized, four-period, four-sequence crossover study, 24 healthy adult subjects (...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hermann, Robert, Mungo, Julius, Cnota, Peter Jürgen, Ziegler, Dan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2014
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258503/ https://www.ncbi.nlm.nih.gov/pubmed/25506250 http://dx.doi.org/10.2147/CPAA.S71574

Ejemplares similares

Zein-alpha lipoic acid-loaded nanoparticles to enhance the oral bioavailability of dapoxetine: optimization and clinical pharmacokinetic evaluation
por: El-Say, Khalid M, et al.
Publicado: (2019)

Pharmacokinetics and Relative Bioavailability of Flavonoids between Two Dosage Forms of Gegen-Qinlian-Tang in Rats
por: Yu, Chung-Ping, et al.
Publicado: (2012)

P02.183. Comparing the bioavailability of two forms of lipoic acid in multiple sclerosis
por: Salinthone, S, et al.
Publicado: (2012)

Alpha-Lipoic Acid and Its Enantiomers Prevent Methemoglobin Formation and DNA Damage Induced by Dapsone Hydroxylamine: Molecular Mechanism and Antioxidant Action
por: Espíndola, Kaio Murilo Monteiro, et al.
Publicado: (2022)

A Pharmacokinetic Study of Mix-160 by LC-MS/MS: Oral Bioavailability of a Dosage Form of Citroflavonoids Mixture
por: Araujo-León, Jesús Alfredo, et al.
Publicado: (2022)

Diabetes and Alpha Lipoic Acid
por: Golbidi, Saeid, et al.
Publicado: (2011)

Innovations in the Management of Musculoskeletal Pain With Alpha-Lipoic Acid (IMPALA Trial): Study protocol for a Double-Blind, Randomized, Placebo-Controlled Crossover Trial of Alpha-Lipoic Acid for the Treatment of Fibromyalgia Pain
por: Gilron, Ian, et al.
Publicado: (2017)

Comparison of Coated and Immobilized Chiral Stationary Phases Based on Amylose tris-[(S)-α-Methylbenzylcarbamate] for the HPLC Enantiomer Separation of α-Lipoic Acid and Its Reduced Form
por: Rosetti, Alessia, et al.
Publicado: (2021)

Comparative pharmacokinetics and tissue distribution of primaquine enantiomers in mice
por: Fasinu, Pius S., et al.
Publicado: (2022)

Development of a Stability-Indicating Stereoselective Method for Quantification of the Enantiomer in the Drug Substance and Pharmaceutical Dosage Form of Rosuvastatin Calcium by an Enhanced Approach
por: Rajendra Reddy, Gangireddy, et al.
Publicado: (2015)

Enantioselective Pharmacokinetics of α-Lipoic Acid in Rats
por: Uchida, Ryota, et al.
Publicado: (2015)

The Role of Functional Excipients in Solid Oral Dosage Forms to Overcome Poor Drug Dissolution and Bioavailability
por: van der Merwe, Jannes, et al.
Publicado: (2020)

Prediction of pharmacokinetic values of two various dosages of caffeine in premature neonates with apnea
por: Faramarzi, Fatemeh, et al.
Publicado: (2021)

Alpha-lipoic acid intoxication in an adolescent girl
por: Al-Mendalawi, Mahmood D.
Publicado: (2021)

Bioavailability of an R-α-Lipoic Acid/γ-Cyclodextrin Complex in Healthy Volunteers
por: Ikuta, Naoko, et al.
Publicado: (2016)

Development and single dose clinical pharmacokinetics investigation of novel zein assisted- alpha lipoic acid nanoencapsulation of vardenafil
por: Ahmed, Osama A. A.
Publicado: (2018)

An Overview of the Antioxidant Effects of Ascorbic Acid and Alpha Lipoic Acid (in Liposomal Forms) as Adjuvant in Cancer Treatment
por: Attia, Mohamed, et al.
Publicado: (2020)

The influence of alpha-melanocortin enantiomers on acetaminophen-induced hepatis in mice
por: Turčić, Petra, et al.
Publicado: (2012)

Surface tension examination of various liquid oral, nasal, and ophthalmic dosage forms
por: Han, Kimberly, et al.
Publicado: (2016)

Enantiomer specific pharmacokinetics of ibuprofen in preterm neonates with patent ductus arteriosus
por: Engbers, Aline G.J., et al.
Publicado: (2020)

Dietary Alpha-Lipoic Acid Alters Piglet Neurodevelopment
por: Mudd, Austin T., et al.
Publicado: (2016)

The Immunomodulatory Effect of Alpha-Lipoic Acid in Autoimmune Diseases
por: Liu, Wei, et al.
Publicado: (2019)

Re: Alpha-lipoic acid intoxication in an adolescent girl
por: Polat, Sinem, et al.
Publicado: (2021)

Enantioselective Separation of 4,8-DHT and Phytotoxicity of the Enantiomers on Various Plant Species
por: Yang, Li, et al.
Publicado: (2016)

Mechanism of alpha-lipoic acid in attenuating kanamycin-induced ototoxicity☆
por: Wang, Aimei, et al.
Publicado: (2012)

Alpha-Lipoic Acid as an Antioxidant Strategy for Managing Neuropathic Pain
por: Viana, Max Denisson Maurício, et al.
Publicado: (2022)

Alpha Lipoic Acid Efficacy in PCOS Treatment: What Is the Truth?
por: Guarano, Alice, et al.
Publicado: (2023)

Prediction for optimal dosage of pazopanib under various clinical situations using physiologically based pharmacokinetic modeling
por: Wu, Chunnuan, et al.
Publicado: (2022)

Lipoic Acid Pharmacokinetics at Baseline and 1 year in Secondary Progressive MS
por: Bittner, Frank, et al.
Publicado: (2017)

Development of a Standardized Method for Measuring Bioadhesion and Mucoadhesion That Is Applicable to Various Pharmaceutical Dosage Forms
por: Amorós-Galicia, Lola, et al.
Publicado: (2022)

Asymmetric Synthesis of Contact Sex Pheromone of Tetropium fuscum and Its Enantiomer
por: Wang, Xueyang, et al.
Publicado: (2022)

Separation and determination of acetyl-glutamine enantiomers by HPLC–MS and its application in pharmacokinetic study
por: Zhang, Xiaoxiao, et al.
Publicado: (2017)

Comparative single dose pharmacokinetics and metabolism of racemic primaquine and its enantiomers in human volunteers
por: Khan, Washim, et al.
Publicado: (2022)

Complex Hydrogels Composed of Chitosan with Ring-opened Polyvinyl Pyrrolidone as a Gastroretentive Drug Dosage Form to Enhance the Bioavailability of Bisphosphonates
por: Su, Chia-Yu, et al.
Publicado: (2018)

Formulation and evaluation of cyclodextrin-based nanosponges of griseofulvin as pediatric oral liquid dosage form for enhancing bioavailability and masking bitter taste
por: Omar, Samia M., et al.
Publicado: (2020)

Lipid Lowering Effect of Antioxidant Alpha-Lipoic Acid in Experimental Atherosclerosis
por: Amom, Zulkhairi, et al.
Publicado: (2008)

Redox homeostasis of albumin in relation to alpha-lipoic acid and dihydrolipoic acid
por: Atukeren, Pinar, et al.
Publicado: (2010)

A Study of the Antioxidant Effect of Alpha Lipoic Acids on Sperm Quality
por: Ibrahim, Siti Fatimah, et al.
Publicado: (2008)

The effect of alpha lipoic acid ingestion on glucose uptake in healthy males
por: Mandic, Iva, et al.
Publicado: (2011)

Possible role of alpha-lipoic acid in the treatment of peripheral nerve injuries
por: Ranieri, Maurizio, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_b712n9somv4i7350cj3am0umn7