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Differences between murine arylamine N-acetyltransferase type 1 and human arylamine N-acetyltransferase type 2 defined by substrate specificity and inhibitor binding

BACKGROUND: The mouse has three arylamine N-acetyltransferase genes, (MOUSE)Nat1, (MOUSE)Nat2 and (MOUSE)Nat3. These are believed to correspond to (HUMAN)NAT1, (HUMAN)NAT2 and NATP in humans. (MOUSE)Nat3 encodes an enzyme with poor activity and human NATP is a pseudogene. (MOUSE)Nat2 is orthologous...

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Detalles Bibliográficos
Autores principales:	Laurieri, Nicola, Kawamura, Akane, Westwood, Isaac M, Varney, Amy, Morris, Elizabeth, Russell, Angela J, Stanley, Lesley A, Sim, Edith
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258814/ https://www.ncbi.nlm.nih.gov/pubmed/25432241 http://dx.doi.org/10.1186/2050-6511-15-68

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