A Previously Unknown Unique Challenge for Inhibitors of SYK ATP-Binding Site: Role of SYK as A Cell Cycle Checkpoint Regulator()

The identification of SYK as a molecular target in B-lineage leukemia/lymphoma cells prompted the development of SYK inhibitors as a new class of anti-cancer drug candidates. Here we report that induction of the SYK gene expression in human cells causes a significant down-regulation of evolutionaril...

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Detalles Bibliográficos
Autores principales: Uckun, Fatih M., Ma, Hong, Ozer, Zahide, Goodman, Patricia, Zhang, Jian, Qazi, Sanjive
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259291/
https://www.ncbi.nlm.nih.gov/pubmed/25506060
http://dx.doi.org/10.1016/j.ebiom.2014.10.019

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