Glycogen Synthase Kinase 3 Protein Kinase Activity Is Frequently Elevated in Human Non-Small Cell Lung Carcinoma and Supports Tumour Cell Proliferation

BACKGROUND: Glycogen synthase kinase 3 (GSK3) is a central regulator of cellular metabolism, development and growth. GSK3 activity was thought to oppose tumourigenesis, yet recent studies indicate that it may support tumour growth in some cancer types including in non-small cell lung carcinoma (NSCL...

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Detalles Bibliográficos
Autores principales: Vincent, Emma E., Elder, Douglas J. E., O′Flaherty, Linda, Pardo, Olivier E., Dzien, Piotr, Phillips, Lois, Morgan, Carys, Pawade, Joya, May, Margaret T., Sohail, Muhammad, Hetzel, Martin R., Seckl, Michael J., Tavaré, Jeremy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259366/
https://www.ncbi.nlm.nih.gov/pubmed/25486534
http://dx.doi.org/10.1371/journal.pone.0114725

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