Intratumoral administration of mRNA encoding a fusokine consisting of IFN-β and the ectodomain of the TGF-β receptor II potentiates antitumor immunity

It is generally accepted that the success of immunotherapy depends on the presence of tumor-specific CD8(+) cytotoxic T cells and the modulation of the tumor environment. In this study, we validated mRNA encoding soluble factors as a tool to modulate the tumor microenvironment to potentiate infiltra...

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Detalles Bibliográficos
Autores principales: Van der Jeught, Kevin, Joe, Patrick Tjok, Bialkowski, Lukasz, Heirman, Carlo, Daszkiewicz, Lidia, Liechtenstein, Therese, Escors, David, Thielemans, Kris, Breckpot, Karine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259408/
https://www.ncbi.nlm.nih.gov/pubmed/25338019

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