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Chemoradiation provides a physiological selective pressure that increases the expansion of aberrant TP53 tumor variants in residual rectal cancerous regions

Neoadjuvant chemoradiotherapy has been introduced in patients with surgically resected rectal cancer and reduced the local recurrence. Heterogeneity exists in rectal cancer, and we hypothesized that there are subclones resistant to chemoradiotherapy within the cancer mass. We performed DNA-targeted...

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Detalles Bibliográficos
Autores principales:	Sakai, Kazuko, Kazama, Shinsuke, Nagai, Yuzo, Murono, Koji, Tanaka, Toshiaki, Ishihara, Soichiro, Sunami, Eiji, Tomida, Shuta, Nishio, Kazuto, Watanabe, Toshiaki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2014
Materias:	Clinical Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259426/ https://www.ncbi.nlm.nih.gov/pubmed/25275295

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