Diacylglycerol kinase α promotes 3D cancer cell growth and limits drug sensitivity through functional interaction with Src

Diacylglycerol kinase (DGK)α converts diacylglycerol to phosphatidic acid. This lipid kinase sustains survival, migration and invasion of tumor cells, with no effect over untransformed cells, suggesting its potential as a cancer-specific target. Nonetheless the mechanisms that underlie DGKα specific...

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Detalles Bibliográficos
Autores principales: Torres-Ayuso, Pedro, Daza-Martín, Manuel, Martín-Pérez, Jorge, Ávila-Flores, Antonia, Mérida, Isabel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259432/
https://www.ncbi.nlm.nih.gov/pubmed/25339152

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