Combined VEGF and CXCR4 antagonism targets the GBM stem cell population and synergistically improves survival in an intracranial mouse model of glioblastoma

Glioblastoma recurrence involves the persistence of a subpopulation of cells with enhanced tumor-initiating capacity (TIC) that reside within the perivascular space, or niche (PVN). Anti-angiogenic therapies may prevent the formation of new PVN but have not prevented recurrence in clinical trials, s...

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Detalles Bibliográficos
Autores principales: Barone, Amy, Sengupta, Rajarshi, Warrington, Nicole M., Smith, Erin, Wen, Patrick Y., Brekken, Rolf A., Romagnoli, Barbara, Douglas, Garry, Chevalier, Eric, Bauer, Michael P., Dembowsky, Klaus, Piwnica-Worms, David, Rubin, Joshua B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259439/
https://www.ncbi.nlm.nih.gov/pubmed/25238146

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