A novel action mechanism for MPT0G013, a derivative of arylsulfonamide, inhibits tumor angiogenesis through up-regulation of TIMP3 expression

Tissue inhibitors of metalloproteinases 3 (TIMP3) were originally characterized as inhibitors of matrix metalloproteinases (MMPs), acting as potent antiangiogenic proteins. In this study, we demonstrated that the arylsulfonamide derivative MPT0G013 has potent antiangiogenic activities in vitro and i...

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Detalles Bibliográficos
Autores principales: Wang, Chih-Ya, Liou, Jing-Ping, Tsai, An-Chi, Lai, Mei-Jung, Liu, Yi-Min, Lee, Hsueh-Yun, Wang, Jing-Chi, Pan, Shiow-Lin, Teng, Che-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259441/
https://www.ncbi.nlm.nih.gov/pubmed/25226613

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