Mechanisms of the Pellagragenic Effect of Leucine: Stimulation of Hepatic Tryptophan Oxidation by Administration of Branched-Chain Amino Acids to Healthy Human Volunteers and the Role of Plasma Free Tryptophan and Total Kynurenines

The pellagragenic effect of leucine (Leu) has been proposed to involve modulation of L-tryptophan (Trp) metabolism along the hepatic kynurenine pathway. Here, we discuss some of the mechanisms suggested and report the effects in healthy volunteers of single doses of Leu (4.05–6.75 g) administered in...

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Detalles Bibliográficos
Autores principales: Badawy, Abdulla A-B, Lake, Sarah L, Dougherty, Donald M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259507/
https://www.ncbi.nlm.nih.gov/pubmed/25520560
http://dx.doi.org/10.4137/IJTR.S18231

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259507/
https://www.ncbi.nlm.nih.gov/pubmed/25520560
http://dx.doi.org/10.4137/IJTR.S18231

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