Effect of HLA-B-associated Transcript 3 Polymorphisms on Lung Cancer Risk: A Meta-Analysis

BACKGROUND: The association between the HLA-B-associated transcript 3 polymorphisms and lung cancer risk is a subject of debate. We conducted a meta-analysis to evaluate the association between these polymorphisms and lung cancer susceptibility. MATERIAL/METHODS: A systematic search of electronic da...

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Detalles Bibliográficos
Autores principales: Zhao, Junfei, Wang, Hongyuan, Hu, Weizhen, Jin, Yuanhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2014
Materias:
Meta-Analysis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259522/
https://www.ncbi.nlm.nih.gov/pubmed/25430685
http://dx.doi.org/10.12659/MSM.891141
Descripción
Sumario:BACKGROUND: The association between the HLA-B-associated transcript 3 polymorphisms and lung cancer risk is a subject of debate. We conducted a meta-analysis to evaluate the association between these polymorphisms and lung cancer susceptibility. MATERIAL/METHODS: A systematic search of electronic databases (PubMed, EMBASE, Wanfang, and China National Knowledge Infrastructure) was performed. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated. RESULTS: Ten case-control studies with 37 945 and 56 807 controls were included in this meta-analysis. Overall, a significant association between rs1052486 polymorphism and lung cancer susceptibility was observed (OR=1.07, 95% CI 1.01–1.12, P=0.01). In addition, a significant association was found for rs3117582 polymorphism (OR=1.29, 95% CI 1.22–1.37, P<0.01). CONCLUSIONS: This meta-analysis suggested that HLA-B-associated transcript 3 polymorphisms are risk factors for lung cancer.

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