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Pulsing blue light through closed eyelids: effects on acute melatonin suppression and phase shifting of dim light melatonin onset
Circadian rhythm disturbances parallel the increased prevalence of sleep disorders in older adults. Light therapies that specifically target regulation of the circadian system in principle could be used to treat sleep disorders in this population. Current recommendations for light treatment require...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259558/ https://www.ncbi.nlm.nih.gov/pubmed/25506253 http://dx.doi.org/10.2147/NSS.S73856 |
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author | Figueiro, Mariana G Plitnick, Barbara Rea, Mark S |
author_facet | Figueiro, Mariana G Plitnick, Barbara Rea, Mark S |
author_sort | Figueiro, Mariana G |
collection | PubMed |
description | Circadian rhythm disturbances parallel the increased prevalence of sleep disorders in older adults. Light therapies that specifically target regulation of the circadian system in principle could be used to treat sleep disorders in this population. Current recommendations for light treatment require the patients to sit in front of a bright light box for at least 1 hour daily, perhaps limiting their willingness to comply. Light applied through closed eyelids during sleep might not only be efficacious for changing circadian phase but also lead to better compliance because patients would receive light treatment while sleeping. Reported here are the results of two studies investigating the impact of a train of 480 nm (blue) light pulses presented to the retina through closed eyelids on melatonin suppression (laboratory study) and on delaying circadian phase (field study). Both studies employed a sleep mask that provided narrowband blue light pulses of 2-second duration every 30 seconds from arrays of light-emitting diodes. The results of the laboratory study demonstrated that the blue light pulses significantly suppressed melatonin by an amount similar to that previously shown in the same protocol at half the frequency (ie, one 2-second pulse every minute for 1 hour). The results of the field study demonstrated that blue light pulses given early in the sleep episode significantly delayed circadian phase in older adults; these results are the first to demonstrate the efficacy and practicality of light treatment by a sleep mask aimed at adjusting circadian phase in a home setting. |
format | Online Article Text |
id | pubmed-4259558 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-42595582014-12-12 Pulsing blue light through closed eyelids: effects on acute melatonin suppression and phase shifting of dim light melatonin onset Figueiro, Mariana G Plitnick, Barbara Rea, Mark S Nat Sci Sleep Original Research Circadian rhythm disturbances parallel the increased prevalence of sleep disorders in older adults. Light therapies that specifically target regulation of the circadian system in principle could be used to treat sleep disorders in this population. Current recommendations for light treatment require the patients to sit in front of a bright light box for at least 1 hour daily, perhaps limiting their willingness to comply. Light applied through closed eyelids during sleep might not only be efficacious for changing circadian phase but also lead to better compliance because patients would receive light treatment while sleeping. Reported here are the results of two studies investigating the impact of a train of 480 nm (blue) light pulses presented to the retina through closed eyelids on melatonin suppression (laboratory study) and on delaying circadian phase (field study). Both studies employed a sleep mask that provided narrowband blue light pulses of 2-second duration every 30 seconds from arrays of light-emitting diodes. The results of the laboratory study demonstrated that the blue light pulses significantly suppressed melatonin by an amount similar to that previously shown in the same protocol at half the frequency (ie, one 2-second pulse every minute for 1 hour). The results of the field study demonstrated that blue light pulses given early in the sleep episode significantly delayed circadian phase in older adults; these results are the first to demonstrate the efficacy and practicality of light treatment by a sleep mask aimed at adjusting circadian phase in a home setting. Dove Medical Press 2014-12-02 /pmc/articles/PMC4259558/ /pubmed/25506253 http://dx.doi.org/10.2147/NSS.S73856 Text en © 2014 Figueiro et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Figueiro, Mariana G Plitnick, Barbara Rea, Mark S Pulsing blue light through closed eyelids: effects on acute melatonin suppression and phase shifting of dim light melatonin onset |
title | Pulsing blue light through closed eyelids: effects on acute melatonin suppression and phase shifting of dim light melatonin onset |
title_full | Pulsing blue light through closed eyelids: effects on acute melatonin suppression and phase shifting of dim light melatonin onset |
title_fullStr | Pulsing blue light through closed eyelids: effects on acute melatonin suppression and phase shifting of dim light melatonin onset |
title_full_unstemmed | Pulsing blue light through closed eyelids: effects on acute melatonin suppression and phase shifting of dim light melatonin onset |
title_short | Pulsing blue light through closed eyelids: effects on acute melatonin suppression and phase shifting of dim light melatonin onset |
title_sort | pulsing blue light through closed eyelids: effects on acute melatonin suppression and phase shifting of dim light melatonin onset |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259558/ https://www.ncbi.nlm.nih.gov/pubmed/25506253 http://dx.doi.org/10.2147/NSS.S73856 |
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