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Interleukin-7 Optimizes FOXP3+CD4+ Regulatory T Cells Reactivity to Interleukin-2 by Modulating CD25 Expression

The vast majority of Foxp3 regulatory T cells (Treg) exhibits constitutive expression of CD25 (IL-2Rα), which allows the constitution of the high affinity IL-2Rαβγ receptor, ensuring efficient IL-2 binding by Treg. Maintenance of CD25 expression at Treg surface depends on both cell intrinsic factors...

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Detalles Bibliográficos
Autores principales:	Simonetta, Federico, Gestermann, Nicolas, Bloquet, Stéphane, Bourgeois, Christine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259569/ https://www.ncbi.nlm.nih.gov/pubmed/25485946 http://dx.doi.org/10.1371/journal.pone.0113314

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