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Quantitative proteomics of delirium cerebrospinal fluid
Delirium is a common cause and complication of hospitalization in older people, being associated with higher risk of future dementia and progression of existing dementia. However relatively little data are available on which biochemical pathways are dysregulated in the brain during delirium episodes...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259987/ https://www.ncbi.nlm.nih.gov/pubmed/25369144 http://dx.doi.org/10.1038/tp.2014.114 |
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author | Poljak, A Hill, M Hall, R J MacLullich, A M Raftery, M J Tai, J Yan, S Caplan, G A |
author_facet | Poljak, A Hill, M Hall, R J MacLullich, A M Raftery, M J Tai, J Yan, S Caplan, G A |
author_sort | Poljak, A |
collection | PubMed |
description | Delirium is a common cause and complication of hospitalization in older people, being associated with higher risk of future dementia and progression of existing dementia. However relatively little data are available on which biochemical pathways are dysregulated in the brain during delirium episodes, whether there are protein expression changes common among delirium subjects and whether there are any changes which correlate with the severity of delirium. We now present the first proteomic analysis of delirium cerebrospinal fluid (CSF), and one of few studies exploring protein expression changes in delirium. More than 270 proteins were identified in two delirium cohorts, 16 of which were dysregulated in at least 8 of 17 delirium subjects compared with a mild Alzheimer's disease neurological control group, and 31 proteins were significantly correlated with cognitive scores (mini-mental state exam and acute physiology and chronic health evaluation III). Bioinformatics analyses revealed expression changes in several protein family groups, including apolipoproteins, secretogranins/chromogranins, clotting/fibrinolysis factors, serine protease inhibitors and acute-phase response elements. These data not only provide confirmatory evidence that the inflammatory response is a component of delirium, but also reveal dysregulation of protein expression in a number of novel and unexpected clusters of proteins, in particular the granins. Another surprising outcome of this work is the level of similarity of CSF protein profiles in delirium patients, given the diversity of causes of this syndrome. These data provide additional elements for consideration in the pathophysiology of delirium as well as potential biomarker candidates for delirium diagnosis. |
format | Online Article Text |
id | pubmed-4259987 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-42599872014-12-12 Quantitative proteomics of delirium cerebrospinal fluid Poljak, A Hill, M Hall, R J MacLullich, A M Raftery, M J Tai, J Yan, S Caplan, G A Transl Psychiatry Original Article Delirium is a common cause and complication of hospitalization in older people, being associated with higher risk of future dementia and progression of existing dementia. However relatively little data are available on which biochemical pathways are dysregulated in the brain during delirium episodes, whether there are protein expression changes common among delirium subjects and whether there are any changes which correlate with the severity of delirium. We now present the first proteomic analysis of delirium cerebrospinal fluid (CSF), and one of few studies exploring protein expression changes in delirium. More than 270 proteins were identified in two delirium cohorts, 16 of which were dysregulated in at least 8 of 17 delirium subjects compared with a mild Alzheimer's disease neurological control group, and 31 proteins were significantly correlated with cognitive scores (mini-mental state exam and acute physiology and chronic health evaluation III). Bioinformatics analyses revealed expression changes in several protein family groups, including apolipoproteins, secretogranins/chromogranins, clotting/fibrinolysis factors, serine protease inhibitors and acute-phase response elements. These data not only provide confirmatory evidence that the inflammatory response is a component of delirium, but also reveal dysregulation of protein expression in a number of novel and unexpected clusters of proteins, in particular the granins. Another surprising outcome of this work is the level of similarity of CSF protein profiles in delirium patients, given the diversity of causes of this syndrome. These data provide additional elements for consideration in the pathophysiology of delirium as well as potential biomarker candidates for delirium diagnosis. Nature Publishing Group 2014-11 2014-11-04 /pmc/articles/PMC4259987/ /pubmed/25369144 http://dx.doi.org/10.1038/tp.2014.114 Text en Copyright © 2014 Macmillan Publishers Limited http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/ |
spellingShingle | Original Article Poljak, A Hill, M Hall, R J MacLullich, A M Raftery, M J Tai, J Yan, S Caplan, G A Quantitative proteomics of delirium cerebrospinal fluid |
title | Quantitative proteomics of delirium cerebrospinal fluid |
title_full | Quantitative proteomics of delirium cerebrospinal fluid |
title_fullStr | Quantitative proteomics of delirium cerebrospinal fluid |
title_full_unstemmed | Quantitative proteomics of delirium cerebrospinal fluid |
title_short | Quantitative proteomics of delirium cerebrospinal fluid |
title_sort | quantitative proteomics of delirium cerebrospinal fluid |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259987/ https://www.ncbi.nlm.nih.gov/pubmed/25369144 http://dx.doi.org/10.1038/tp.2014.114 |
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