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Codeine-induced hyperalgesia and allodynia: investigating the role of glial activation

Chronic morphine therapy has been associated with paradoxically increased pain. Codeine is a widely used opioid, which is metabolized to morphine to elicit analgesia. Prolonged morphine exposure exacerbates pain by activating the innate immune toll-like receptor-4 (TLR4) in the central nervous syste...

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Detalles Bibliográficos
Autores principales:	Johnson, J L, Rolan, P E, Johnson, M E, Bobrovskaya, L, Williams, D B, Johnson, K, Tuke, J, Hutchinson, M R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259992/ https://www.ncbi.nlm.nih.gov/pubmed/25386959 http://dx.doi.org/10.1038/tp.2014.121

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