Linking the Population Pharmacokinetics of Tenofovir and Its Metabolites With Its Cellular Uptake and Metabolism

Empirical pharmacokinetic models are used to explain the pharmacokinetics of the antiviral drug tenofovir (TFV) and its metabolite TFV diphosphate (TFV-DP) in peripheral blood mononuclear cells. These empirical models lack the ability to explain differences between the disposition of TFV-DP in HIV-i...

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Detalles Bibliográficos
Autores principales: Madrasi, K, Burns, R N, Hendrix, C W, Fossler, M J, Chaturvedula, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260001/
https://www.ncbi.nlm.nih.gov/pubmed/25390686
http://dx.doi.org/10.1038/psp.2014.46

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