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Mutant PIK3CA controls DUSP1-dependent ERK 1/2 activity to confer response to AKT target therapy

BACKGROUND: Alterations in the phosphoinositide 3-kinase/AKT/mammalian target of rapamycin (PI3K/AKT/mTOR) signalling pathway are frequent in urothelial bladder cancer (BLCA) and thus provide a potential target for novel therapeutic strategies. We investigated the efficacy of the AKT inhibitor MK-22...

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Detalles Bibliográficos
Autores principales:	Sathe, A, Guerth, F, Cronauer, M V, Heck, M M, Thalgott, M, Gschwend, J E, Retz, M, Nawroth, R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Translational Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260039/ https://www.ncbi.nlm.nih.gov/pubmed/25349966 http://dx.doi.org/10.1038/bjc.2014.534

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