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Prevention Strategies for Gastric Cancer: A Global Perspective

Despite the substantial burden of gastric cancer worldwide, population strategies for primary prevention have not been introduced in any country. Recognizing the causal role of Helicobacter pylori infection, there is increasing interest in population-based programs to eradicate the infection to prev...

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Autores principales: Park, Jin Young, von Karsa, Lawrence, Herrero, Rolando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Gastrointestinal Endoscopy 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260094/
https://www.ncbi.nlm.nih.gov/pubmed/25505712
http://dx.doi.org/10.5946/ce.2014.47.6.478
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author Park, Jin Young
von Karsa, Lawrence
Herrero, Rolando
author_facet Park, Jin Young
von Karsa, Lawrence
Herrero, Rolando
author_sort Park, Jin Young
collection PubMed
description Despite the substantial burden of gastric cancer worldwide, population strategies for primary prevention have not been introduced in any country. Recognizing the causal role of Helicobacter pylori infection, there is increasing interest in population-based programs to eradicate the infection to prevent gastric cancer. Nonetheless, the paucity of available evidence on feasibility and effectiveness has prevented implementation of this approach. There are very few secondary prevention programs based on screening with endoscopy or radiography, notably in the Republic of Korea and Japan, two of the countries with the highest incidence rates of gastric cancer. In Korea, where the organized screening program is in place, survival rate of gastric cancer is as high as 67%. More research is needed to quantify the specific contribution of the screening program to observed declines in mortality rates. Gastric cancer screening is unlikely to be feasible in many Low-Middle Income Countries where the gastric cancer burden is high. Prevention strategies are still under development and the optimal approach may differ depending on local conditions and societal values. The present review gives an overview of the etiology and burden of the disease, and possible prevention strategies for countries and regions confronted with a significant burden of disease.
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spelling pubmed-42600942014-12-10 Prevention Strategies for Gastric Cancer: A Global Perspective Park, Jin Young von Karsa, Lawrence Herrero, Rolando Clin Endosc Focused Review Series: Endoscopic Screening and Surveillance for Gastrointestinal Cancer Despite the substantial burden of gastric cancer worldwide, population strategies for primary prevention have not been introduced in any country. Recognizing the causal role of Helicobacter pylori infection, there is increasing interest in population-based programs to eradicate the infection to prevent gastric cancer. Nonetheless, the paucity of available evidence on feasibility and effectiveness has prevented implementation of this approach. There are very few secondary prevention programs based on screening with endoscopy or radiography, notably in the Republic of Korea and Japan, two of the countries with the highest incidence rates of gastric cancer. In Korea, where the organized screening program is in place, survival rate of gastric cancer is as high as 67%. More research is needed to quantify the specific contribution of the screening program to observed declines in mortality rates. Gastric cancer screening is unlikely to be feasible in many Low-Middle Income Countries where the gastric cancer burden is high. Prevention strategies are still under development and the optimal approach may differ depending on local conditions and societal values. The present review gives an overview of the etiology and burden of the disease, and possible prevention strategies for countries and regions confronted with a significant burden of disease. The Korean Society of Gastrointestinal Endoscopy 2014-11 2014-11-30 /pmc/articles/PMC4260094/ /pubmed/25505712 http://dx.doi.org/10.5946/ce.2014.47.6.478 Text en Copyright © 2014 Korean Society of Gastrointestinal Endoscopy http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Focused Review Series: Endoscopic Screening and Surveillance for Gastrointestinal Cancer
Park, Jin Young
von Karsa, Lawrence
Herrero, Rolando
Prevention Strategies for Gastric Cancer: A Global Perspective
title Prevention Strategies for Gastric Cancer: A Global Perspective
title_full Prevention Strategies for Gastric Cancer: A Global Perspective
title_fullStr Prevention Strategies for Gastric Cancer: A Global Perspective
title_full_unstemmed Prevention Strategies for Gastric Cancer: A Global Perspective
title_short Prevention Strategies for Gastric Cancer: A Global Perspective
title_sort prevention strategies for gastric cancer: a global perspective
topic Focused Review Series: Endoscopic Screening and Surveillance for Gastrointestinal Cancer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260094/
https://www.ncbi.nlm.nih.gov/pubmed/25505712
http://dx.doi.org/10.5946/ce.2014.47.6.478
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