A Corin Variant Identified in Hypertensive Patients That Alters Cytoplasmic Tail and Reduces Cell Surface Expression and Activity

Corin is a membrane-bound protease that regulates blood pressure by activating the natriuretic peptides. CORIN variants have been associated with hypertension and heart disease in African Americans. In this study, we conducted targeted exome sequencing and identified an insertion variant, c.102_103i...

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Detalles Bibliográficos
Autores principales: Zhang, Yue, Li, Hui, Zhou, Jianping, Wang, Aili, Yang, Junhua, Wang, Can, Liu, Meng, Zhou, Tiantian, Zhu, Li, Zhang, Yonghong, Dong, Ningzheng, Wu, Qingyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260221/
https://www.ncbi.nlm.nih.gov/pubmed/25488193
http://dx.doi.org/10.1038/srep07378

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