Next-generation sequencing of the mitochondrial genome and association with IgA nephropathy in a renal transplant population

Kidneys are highly aerobic organs that are critically dependent on the normal functioning of mitochondria. Genetic variations disrupting mitochondrial function are associated with multifactorial disorders including kidney disease. This study sequenced the entire mitochondrial genome in a renal trans...

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Autores principales: Douglas, Adam P., Vance, Dwaine R., Kenny, Elaine M., Morris, Derek W., Maxwell, Alexander P., McKnight, Amy Jayne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260226/
https://www.ncbi.nlm.nih.gov/pubmed/25488329
http://dx.doi.org/10.1038/srep07379
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author Douglas, Adam P.
Vance, Dwaine R.
Kenny, Elaine M.
Morris, Derek W.
Maxwell, Alexander P.
McKnight, Amy Jayne
author_facet Douglas, Adam P.
Vance, Dwaine R.
Kenny, Elaine M.
Morris, Derek W.
Maxwell, Alexander P.
McKnight, Amy Jayne
author_sort Douglas, Adam P.
collection PubMed
description Kidneys are highly aerobic organs that are critically dependent on the normal functioning of mitochondria. Genetic variations disrupting mitochondrial function are associated with multifactorial disorders including kidney disease. This study sequenced the entire mitochondrial genome in a renal transplant cohort of 64 individuals, using next-generation sequencing, to evaluate the association of genetic variants with IgA nephropathy and end-stage renal disease (ESRD, n = 100).
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spelling pubmed-42602262014-12-15 Next-generation sequencing of the mitochondrial genome and association with IgA nephropathy in a renal transplant population Douglas, Adam P. Vance, Dwaine R. Kenny, Elaine M. Morris, Derek W. Maxwell, Alexander P. McKnight, Amy Jayne Sci Rep Article Kidneys are highly aerobic organs that are critically dependent on the normal functioning of mitochondria. Genetic variations disrupting mitochondrial function are associated with multifactorial disorders including kidney disease. This study sequenced the entire mitochondrial genome in a renal transplant cohort of 64 individuals, using next-generation sequencing, to evaluate the association of genetic variants with IgA nephropathy and end-stage renal disease (ESRD, n = 100). Nature Publishing Group 2014-12-09 /pmc/articles/PMC4260226/ /pubmed/25488329 http://dx.doi.org/10.1038/srep07379 Text en Copyright © 2014, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Article
Douglas, Adam P.
Vance, Dwaine R.
Kenny, Elaine M.
Morris, Derek W.
Maxwell, Alexander P.
McKnight, Amy Jayne
Next-generation sequencing of the mitochondrial genome and association with IgA nephropathy in a renal transplant population
title Next-generation sequencing of the mitochondrial genome and association with IgA nephropathy in a renal transplant population
title_full Next-generation sequencing of the mitochondrial genome and association with IgA nephropathy in a renal transplant population
title_fullStr Next-generation sequencing of the mitochondrial genome and association with IgA nephropathy in a renal transplant population
title_full_unstemmed Next-generation sequencing of the mitochondrial genome and association with IgA nephropathy in a renal transplant population
title_short Next-generation sequencing of the mitochondrial genome and association with IgA nephropathy in a renal transplant population
title_sort next-generation sequencing of the mitochondrial genome and association with iga nephropathy in a renal transplant population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260226/
https://www.ncbi.nlm.nih.gov/pubmed/25488329
http://dx.doi.org/10.1038/srep07379
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