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Correlation of serum neutrophil gelatinase associated lipocalin with disease severity in hypertensive disorders of pregnancy
BACKGROUND: Vascular endothelial dysfunction is considered central to the pathogenesis of hypertensive disorders of pregnancy (HDP). Serum level of neutrophil gelatinase-associated lipocalin (NGAL) is closely related to endothelial injury. The aim of this study was to examine the correlation of seru...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260273/ https://www.ncbi.nlm.nih.gov/pubmed/25538909 http://dx.doi.org/10.4103/2277-9175.145690 |
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author | Sachan, Rekha Patel, ML Gaurav, Amrita Gangwar, Radheshyam Sachan, Pushpalata |
author_facet | Sachan, Rekha Patel, ML Gaurav, Amrita Gangwar, Radheshyam Sachan, Pushpalata |
author_sort | Sachan, Rekha |
collection | PubMed |
description | BACKGROUND: Vascular endothelial dysfunction is considered central to the pathogenesis of hypertensive disorders of pregnancy (HDP). Serum level of neutrophil gelatinase-associated lipocalin (NGAL) is closely related to endothelial injury. The aim of this study was to examine the correlation of serum NGAL with disease severity in HDP. MATERIALS AND METHODS: This prospective case-control study was carried out for one year. After informed consent, ethical clearance, total 1,850 pregnant women were screened. Analysis was performed on 142 cases of HDP and 31 healthy controls. Quantitative measurement of serum NGAL levels was done by the enzyme linked immunosorbent assay (ELISA) technique, by using sandwich ELISA kit. RESULTS: Mean serum NGAL value in patients with oliguria was significantly higher when compared with non-oliguric patients (P < 0.001). Serum NGAL had a positive correlation with systolic blood pressure (r ~ 0.5973), diastolic blood pressure (r ~ 0.6195), blood urea (r ~ 0.4392), serum creatinine (r ~ 0.6112), serum uric acid (r ~ 0.3878). Sensitivity and specificity of serum NGAL using a cut-off value of 545 pg/ml, for the diagnosis of HDP, was 97.89% and 93.55% respectively, using 95% confidence interval. CONCLUSION: Between the two groups, we found that serum NGAL had a positive correlation with disease severity and better sensitivity and specificity in the evaluation of HDP. |
format | Online Article Text |
id | pubmed-4260273 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-42602732014-12-23 Correlation of serum neutrophil gelatinase associated lipocalin with disease severity in hypertensive disorders of pregnancy Sachan, Rekha Patel, ML Gaurav, Amrita Gangwar, Radheshyam Sachan, Pushpalata Adv Biomed Res Original Article BACKGROUND: Vascular endothelial dysfunction is considered central to the pathogenesis of hypertensive disorders of pregnancy (HDP). Serum level of neutrophil gelatinase-associated lipocalin (NGAL) is closely related to endothelial injury. The aim of this study was to examine the correlation of serum NGAL with disease severity in HDP. MATERIALS AND METHODS: This prospective case-control study was carried out for one year. After informed consent, ethical clearance, total 1,850 pregnant women were screened. Analysis was performed on 142 cases of HDP and 31 healthy controls. Quantitative measurement of serum NGAL levels was done by the enzyme linked immunosorbent assay (ELISA) technique, by using sandwich ELISA kit. RESULTS: Mean serum NGAL value in patients with oliguria was significantly higher when compared with non-oliguric patients (P < 0.001). Serum NGAL had a positive correlation with systolic blood pressure (r ~ 0.5973), diastolic blood pressure (r ~ 0.6195), blood urea (r ~ 0.4392), serum creatinine (r ~ 0.6112), serum uric acid (r ~ 0.3878). Sensitivity and specificity of serum NGAL using a cut-off value of 545 pg/ml, for the diagnosis of HDP, was 97.89% and 93.55% respectively, using 95% confidence interval. CONCLUSION: Between the two groups, we found that serum NGAL had a positive correlation with disease severity and better sensitivity and specificity in the evaluation of HDP. Medknow Publications & Media Pvt Ltd 2014-11-29 /pmc/articles/PMC4260273/ /pubmed/25538909 http://dx.doi.org/10.4103/2277-9175.145690 Text en Copyright: © 2014 Sachan. http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Original Article Sachan, Rekha Patel, ML Gaurav, Amrita Gangwar, Radheshyam Sachan, Pushpalata Correlation of serum neutrophil gelatinase associated lipocalin with disease severity in hypertensive disorders of pregnancy |
title | Correlation of serum neutrophil gelatinase associated lipocalin with disease severity in hypertensive disorders of pregnancy |
title_full | Correlation of serum neutrophil gelatinase associated lipocalin with disease severity in hypertensive disorders of pregnancy |
title_fullStr | Correlation of serum neutrophil gelatinase associated lipocalin with disease severity in hypertensive disorders of pregnancy |
title_full_unstemmed | Correlation of serum neutrophil gelatinase associated lipocalin with disease severity in hypertensive disorders of pregnancy |
title_short | Correlation of serum neutrophil gelatinase associated lipocalin with disease severity in hypertensive disorders of pregnancy |
title_sort | correlation of serum neutrophil gelatinase associated lipocalin with disease severity in hypertensive disorders of pregnancy |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260273/ https://www.ncbi.nlm.nih.gov/pubmed/25538909 http://dx.doi.org/10.4103/2277-9175.145690 |
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