Study of association between promoter tumor necrosing factor alpha gene polymorphisms in -850T/C, -863 A/C, and endometriosis

BACKGROUND: The purpose of this study was to determine whether variability in gene encoding for promoter of tumor necrosis factor participates to women differences in susceptibility to endometriosis. MATERIALS AND METHODS: The study involved 130 women; 65 endometriotic and 65 healthy control women....

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Detalles Bibliográficos
Autores principales: Mardanian, Farahnaz, Aboutorabi, Roshanak, Jefride, Yalda, Amini, Guilda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260278/
https://www.ncbi.nlm.nih.gov/pubmed/25538912
http://dx.doi.org/10.4103/2277-9175.145706
Descripción
Sumario:BACKGROUND: The purpose of this study was to determine whether variability in gene encoding for promoter of tumor necrosis factor participates to women differences in susceptibility to endometriosis. MATERIALS AND METHODS: The study involved 130 women; 65 endometriotic and 65 healthy control women. The blood samples were genotyped for -850 T/C and -863 C/A polymorphisms in TNF alpha gene promoter. Chi-square, odd ratio, and confidence interval 95% were used to evaluate genotypes and allele frequency differences between two groups. RESULTS: No significant differences in genotypes distribution of -850 T/C (P = 0.32) and 863 C/A (P = 0.34) polymorphisms were obtained between two groups. CONCLUSION: According to this study, these two polymorphisms have no risk or protective factor to develop endometriosis.

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