Study of association between promoter tumor necrosing factor alpha gene polymorphisms in -850T/C, -863 A/C, and endometriosis

BACKGROUND: The purpose of this study was to determine whether variability in gene encoding for promoter of tumor necrosis factor participates to women differences in susceptibility to endometriosis. MATERIALS AND METHODS: The study involved 130 women; 65 endometriotic and 65 healthy control women....

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Autores principales: Mardanian, Farahnaz, Aboutorabi, Roshanak, Jefride, Yalda, Amini, Guilda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260278/
https://www.ncbi.nlm.nih.gov/pubmed/25538912
http://dx.doi.org/10.4103/2277-9175.145706
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author Mardanian, Farahnaz
Aboutorabi, Roshanak
Jefride, Yalda
Amini, Guilda
author_facet Mardanian, Farahnaz
Aboutorabi, Roshanak
Jefride, Yalda
Amini, Guilda
author_sort Mardanian, Farahnaz
collection PubMed
description BACKGROUND: The purpose of this study was to determine whether variability in gene encoding for promoter of tumor necrosis factor participates to women differences in susceptibility to endometriosis. MATERIALS AND METHODS: The study involved 130 women; 65 endometriotic and 65 healthy control women. The blood samples were genotyped for -850 T/C and -863 C/A polymorphisms in TNF alpha gene promoter. Chi-square, odd ratio, and confidence interval 95% were used to evaluate genotypes and allele frequency differences between two groups. RESULTS: No significant differences in genotypes distribution of -850 T/C (P = 0.32) and 863 C/A (P = 0.34) polymorphisms were obtained between two groups. CONCLUSION: According to this study, these two polymorphisms have no risk or protective factor to develop endometriosis.
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spelling pubmed-42602782014-12-23 Study of association between promoter tumor necrosing factor alpha gene polymorphisms in -850T/C, -863 A/C, and endometriosis Mardanian, Farahnaz Aboutorabi, Roshanak Jefride, Yalda Amini, Guilda Adv Biomed Res Original Article BACKGROUND: The purpose of this study was to determine whether variability in gene encoding for promoter of tumor necrosis factor participates to women differences in susceptibility to endometriosis. MATERIALS AND METHODS: The study involved 130 women; 65 endometriotic and 65 healthy control women. The blood samples were genotyped for -850 T/C and -863 C/A polymorphisms in TNF alpha gene promoter. Chi-square, odd ratio, and confidence interval 95% were used to evaluate genotypes and allele frequency differences between two groups. RESULTS: No significant differences in genotypes distribution of -850 T/C (P = 0.32) and 863 C/A (P = 0.34) polymorphisms were obtained between two groups. CONCLUSION: According to this study, these two polymorphisms have no risk or protective factor to develop endometriosis. Medknow Publications & Media Pvt Ltd 2014-11-29 /pmc/articles/PMC4260278/ /pubmed/25538912 http://dx.doi.org/10.4103/2277-9175.145706 Text en Copyright: © 2014 Mardanian. http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Original Article
Mardanian, Farahnaz
Aboutorabi, Roshanak
Jefride, Yalda
Amini, Guilda
Study of association between promoter tumor necrosing factor alpha gene polymorphisms in -850T/C, -863 A/C, and endometriosis
title Study of association between promoter tumor necrosing factor alpha gene polymorphisms in -850T/C, -863 A/C, and endometriosis
title_full Study of association between promoter tumor necrosing factor alpha gene polymorphisms in -850T/C, -863 A/C, and endometriosis
title_fullStr Study of association between promoter tumor necrosing factor alpha gene polymorphisms in -850T/C, -863 A/C, and endometriosis
title_full_unstemmed Study of association between promoter tumor necrosing factor alpha gene polymorphisms in -850T/C, -863 A/C, and endometriosis
title_short Study of association between promoter tumor necrosing factor alpha gene polymorphisms in -850T/C, -863 A/C, and endometriosis
title_sort study of association between promoter tumor necrosing factor alpha gene polymorphisms in -850t/c, -863 a/c, and endometriosis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260278/
https://www.ncbi.nlm.nih.gov/pubmed/25538912
http://dx.doi.org/10.4103/2277-9175.145706
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