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Blood transfusion practices in cancer surgery

Cancer patients are commonly transfused with blood products immediately before, during or after major surgery. Blood loss and haemodilution are the most common causes of red blood cells (RBCs) administration and coagulopathies are the indications for the infusion of fresh-frozen plasma (FFP), cryopr...

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Detalles Bibliográficos
Autores principales: Cata, Juan P, Gottumukkala, Vijaya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260312/
https://www.ncbi.nlm.nih.gov/pubmed/25535428
http://dx.doi.org/10.4103/0019-5049.144675
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author Cata, Juan P
Gottumukkala, Vijaya
author_facet Cata, Juan P
Gottumukkala, Vijaya
author_sort Cata, Juan P
collection PubMed
description Cancer patients are commonly transfused with blood products immediately before, during or after major surgery. Blood loss and haemodilution are the most common causes of red blood cells (RBCs) administration and coagulopathies are the indications for the infusion of fresh-frozen plasma (FFP), cryoprecipitates and platelets. Transfusion-related immune modulation is a complication associated with the administration of blood products. A decreased immune surveillance as a consequence of blood transfusions has been linked to cancer recurrence and progression. Moreover, soluble factors present in packed RBCs, platelets and FFP can directly stimulate tumour growth and spread. Two meta-analyses suggest that the administration of blood products is associated with shorter recurrence-free survival and overall survival after colorectal cancer surgery. More studies are needed to show such association in different cancer patient populations.
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spelling pubmed-42603122014-12-22 Blood transfusion practices in cancer surgery Cata, Juan P Gottumukkala, Vijaya Indian J Anaesth Review Article Cancer patients are commonly transfused with blood products immediately before, during or after major surgery. Blood loss and haemodilution are the most common causes of red blood cells (RBCs) administration and coagulopathies are the indications for the infusion of fresh-frozen plasma (FFP), cryoprecipitates and platelets. Transfusion-related immune modulation is a complication associated with the administration of blood products. A decreased immune surveillance as a consequence of blood transfusions has been linked to cancer recurrence and progression. Moreover, soluble factors present in packed RBCs, platelets and FFP can directly stimulate tumour growth and spread. Two meta-analyses suggest that the administration of blood products is associated with shorter recurrence-free survival and overall survival after colorectal cancer surgery. More studies are needed to show such association in different cancer patient populations. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4260312/ /pubmed/25535428 http://dx.doi.org/10.4103/0019-5049.144675 Text en Copyright: © Indian Journal of Anaesthesia http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Cata, Juan P
Gottumukkala, Vijaya
Blood transfusion practices in cancer surgery
title Blood transfusion practices in cancer surgery
title_full Blood transfusion practices in cancer surgery
title_fullStr Blood transfusion practices in cancer surgery
title_full_unstemmed Blood transfusion practices in cancer surgery
title_short Blood transfusion practices in cancer surgery
title_sort blood transfusion practices in cancer surgery
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260312/
https://www.ncbi.nlm.nih.gov/pubmed/25535428
http://dx.doi.org/10.4103/0019-5049.144675
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