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Targeting the neuropeptide Y system in stress-related psychiatric disorders

Repeated, extreme, or traumatic stressors can elicit pathological effects leading to many negative physical and psychological outcomes. Stressors can precipitate the onset of psychiatric diseases, or exacerbate pre-existing disorders including various anxiety and mood disorders. As stressors can neg...

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Detalles Bibliográficos
Autores principales: Enman, Nicole M., Sabban, Esther L., McGonigle, Paul, Van Bockstaele, Elisabeth J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260418/
https://www.ncbi.nlm.nih.gov/pubmed/25506604
http://dx.doi.org/10.1016/j.ynstr.2014.09.007
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author Enman, Nicole M.
Sabban, Esther L.
McGonigle, Paul
Van Bockstaele, Elisabeth J.
author_facet Enman, Nicole M.
Sabban, Esther L.
McGonigle, Paul
Van Bockstaele, Elisabeth J.
author_sort Enman, Nicole M.
collection PubMed
description Repeated, extreme, or traumatic stressors can elicit pathological effects leading to many negative physical and psychological outcomes. Stressors can precipitate the onset of psychiatric diseases, or exacerbate pre-existing disorders including various anxiety and mood disorders. As stressors can negatively impact human psychiatric health, it is essential to identify neurochemicals that may confer protection from the negative sequelae of repeated or extreme stress exposure. Elucidating the neurobiological underpinnings of stress resilience will enhance our ability to promote resilience to, or recovery from, stress-related psychiatric disease. Herein, we will review the evidence for neuropeptide Y as an endogenous mediator of resilience and its potential relevance for the treatment of stress-related psychiatric diseases.
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spelling pubmed-42604182016-01-01 Targeting the neuropeptide Y system in stress-related psychiatric disorders Enman, Nicole M. Sabban, Esther L. McGonigle, Paul Van Bockstaele, Elisabeth J. Neurobiol Stress Review Article Repeated, extreme, or traumatic stressors can elicit pathological effects leading to many negative physical and psychological outcomes. Stressors can precipitate the onset of psychiatric diseases, or exacerbate pre-existing disorders including various anxiety and mood disorders. As stressors can negatively impact human psychiatric health, it is essential to identify neurochemicals that may confer protection from the negative sequelae of repeated or extreme stress exposure. Elucidating the neurobiological underpinnings of stress resilience will enhance our ability to promote resilience to, or recovery from, stress-related psychiatric disease. Herein, we will review the evidence for neuropeptide Y as an endogenous mediator of resilience and its potential relevance for the treatment of stress-related psychiatric diseases. Elsevier 2014-10-16 /pmc/articles/PMC4260418/ /pubmed/25506604 http://dx.doi.org/10.1016/j.ynstr.2014.09.007 Text en © 2014 The Authors http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open access article under the CC BY-NC-SA license (http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Review Article
Enman, Nicole M.
Sabban, Esther L.
McGonigle, Paul
Van Bockstaele, Elisabeth J.
Targeting the neuropeptide Y system in stress-related psychiatric disorders
title Targeting the neuropeptide Y system in stress-related psychiatric disorders
title_full Targeting the neuropeptide Y system in stress-related psychiatric disorders
title_fullStr Targeting the neuropeptide Y system in stress-related psychiatric disorders
title_full_unstemmed Targeting the neuropeptide Y system in stress-related psychiatric disorders
title_short Targeting the neuropeptide Y system in stress-related psychiatric disorders
title_sort targeting the neuropeptide y system in stress-related psychiatric disorders
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260418/
https://www.ncbi.nlm.nih.gov/pubmed/25506604
http://dx.doi.org/10.1016/j.ynstr.2014.09.007
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