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Targeting the neuropeptide Y system in stress-related psychiatric disorders
Repeated, extreme, or traumatic stressors can elicit pathological effects leading to many negative physical and psychological outcomes. Stressors can precipitate the onset of psychiatric diseases, or exacerbate pre-existing disorders including various anxiety and mood disorders. As stressors can neg...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260418/ https://www.ncbi.nlm.nih.gov/pubmed/25506604 http://dx.doi.org/10.1016/j.ynstr.2014.09.007 |
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author | Enman, Nicole M. Sabban, Esther L. McGonigle, Paul Van Bockstaele, Elisabeth J. |
author_facet | Enman, Nicole M. Sabban, Esther L. McGonigle, Paul Van Bockstaele, Elisabeth J. |
author_sort | Enman, Nicole M. |
collection | PubMed |
description | Repeated, extreme, or traumatic stressors can elicit pathological effects leading to many negative physical and psychological outcomes. Stressors can precipitate the onset of psychiatric diseases, or exacerbate pre-existing disorders including various anxiety and mood disorders. As stressors can negatively impact human psychiatric health, it is essential to identify neurochemicals that may confer protection from the negative sequelae of repeated or extreme stress exposure. Elucidating the neurobiological underpinnings of stress resilience will enhance our ability to promote resilience to, or recovery from, stress-related psychiatric disease. Herein, we will review the evidence for neuropeptide Y as an endogenous mediator of resilience and its potential relevance for the treatment of stress-related psychiatric diseases. |
format | Online Article Text |
id | pubmed-4260418 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-42604182016-01-01 Targeting the neuropeptide Y system in stress-related psychiatric disorders Enman, Nicole M. Sabban, Esther L. McGonigle, Paul Van Bockstaele, Elisabeth J. Neurobiol Stress Review Article Repeated, extreme, or traumatic stressors can elicit pathological effects leading to many negative physical and psychological outcomes. Stressors can precipitate the onset of psychiatric diseases, or exacerbate pre-existing disorders including various anxiety and mood disorders. As stressors can negatively impact human psychiatric health, it is essential to identify neurochemicals that may confer protection from the negative sequelae of repeated or extreme stress exposure. Elucidating the neurobiological underpinnings of stress resilience will enhance our ability to promote resilience to, or recovery from, stress-related psychiatric disease. Herein, we will review the evidence for neuropeptide Y as an endogenous mediator of resilience and its potential relevance for the treatment of stress-related psychiatric diseases. Elsevier 2014-10-16 /pmc/articles/PMC4260418/ /pubmed/25506604 http://dx.doi.org/10.1016/j.ynstr.2014.09.007 Text en © 2014 The Authors http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open access article under the CC BY-NC-SA license (http://creativecommons.org/licenses/by-nc-sa/3.0/). |
spellingShingle | Review Article Enman, Nicole M. Sabban, Esther L. McGonigle, Paul Van Bockstaele, Elisabeth J. Targeting the neuropeptide Y system in stress-related psychiatric disorders |
title | Targeting the neuropeptide Y system in stress-related psychiatric disorders |
title_full | Targeting the neuropeptide Y system in stress-related psychiatric disorders |
title_fullStr | Targeting the neuropeptide Y system in stress-related psychiatric disorders |
title_full_unstemmed | Targeting the neuropeptide Y system in stress-related psychiatric disorders |
title_short | Targeting the neuropeptide Y system in stress-related psychiatric disorders |
title_sort | targeting the neuropeptide y system in stress-related psychiatric disorders |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260418/ https://www.ncbi.nlm.nih.gov/pubmed/25506604 http://dx.doi.org/10.1016/j.ynstr.2014.09.007 |
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