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Optogenetic dissection of medial prefrontal cortex circuitry

The medial prefrontal cortex (mPFC) is critically involved in numerous cognitive functions, including attention, inhibitory control, habit formation, working memory and long-term memory. Moreover, through its dense interconnectivity with subcortical regions (e.g., thalamus, striatum, amygdala and hi...

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Autores principales: Riga, Danai, Matos, Mariana R., Glas, Annet, Smit, August B., Spijker, Sabine, Van den Oever, Michel C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260491/
https://www.ncbi.nlm.nih.gov/pubmed/25538574
http://dx.doi.org/10.3389/fnsys.2014.00230
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author Riga, Danai
Matos, Mariana R.
Glas, Annet
Smit, August B.
Spijker, Sabine
Van den Oever, Michel C.
author_facet Riga, Danai
Matos, Mariana R.
Glas, Annet
Smit, August B.
Spijker, Sabine
Van den Oever, Michel C.
author_sort Riga, Danai
collection PubMed
description The medial prefrontal cortex (mPFC) is critically involved in numerous cognitive functions, including attention, inhibitory control, habit formation, working memory and long-term memory. Moreover, through its dense interconnectivity with subcortical regions (e.g., thalamus, striatum, amygdala and hippocampus), the mPFC is thought to exert top-down executive control over the processing of aversive and appetitive stimuli. Because the mPFC has been implicated in the processing of a wide range of cognitive and emotional stimuli, it is thought to function as a central hub in the brain circuitry mediating symptoms of psychiatric disorders. New optogenetics technology enables anatomical and functional dissection of mPFC circuitry with unprecedented spatial and temporal resolution. This provides important novel insights in the contribution of specific neuronal subpopulations and their connectivity to mPFC function in health and disease states. In this review, we present the current knowledge obtained with optogenetic methods concerning mPFC function and dysfunction and integrate this with findings from traditional intervention approaches used to investigate the mPFC circuitry in animal models of cognitive processing and psychiatric disorders.
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spelling pubmed-42604912014-12-23 Optogenetic dissection of medial prefrontal cortex circuitry Riga, Danai Matos, Mariana R. Glas, Annet Smit, August B. Spijker, Sabine Van den Oever, Michel C. Front Syst Neurosci Neuroscience The medial prefrontal cortex (mPFC) is critically involved in numerous cognitive functions, including attention, inhibitory control, habit formation, working memory and long-term memory. Moreover, through its dense interconnectivity with subcortical regions (e.g., thalamus, striatum, amygdala and hippocampus), the mPFC is thought to exert top-down executive control over the processing of aversive and appetitive stimuli. Because the mPFC has been implicated in the processing of a wide range of cognitive and emotional stimuli, it is thought to function as a central hub in the brain circuitry mediating symptoms of psychiatric disorders. New optogenetics technology enables anatomical and functional dissection of mPFC circuitry with unprecedented spatial and temporal resolution. This provides important novel insights in the contribution of specific neuronal subpopulations and their connectivity to mPFC function in health and disease states. In this review, we present the current knowledge obtained with optogenetic methods concerning mPFC function and dysfunction and integrate this with findings from traditional intervention approaches used to investigate the mPFC circuitry in animal models of cognitive processing and psychiatric disorders. Frontiers Media S.A. 2014-12-09 /pmc/articles/PMC4260491/ /pubmed/25538574 http://dx.doi.org/10.3389/fnsys.2014.00230 Text en Copyright © 2014 Riga, Matos, Glas, Smit, Spijker and Van den Oever. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Riga, Danai
Matos, Mariana R.
Glas, Annet
Smit, August B.
Spijker, Sabine
Van den Oever, Michel C.
Optogenetic dissection of medial prefrontal cortex circuitry
title Optogenetic dissection of medial prefrontal cortex circuitry
title_full Optogenetic dissection of medial prefrontal cortex circuitry
title_fullStr Optogenetic dissection of medial prefrontal cortex circuitry
title_full_unstemmed Optogenetic dissection of medial prefrontal cortex circuitry
title_short Optogenetic dissection of medial prefrontal cortex circuitry
title_sort optogenetic dissection of medial prefrontal cortex circuitry
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260491/
https://www.ncbi.nlm.nih.gov/pubmed/25538574
http://dx.doi.org/10.3389/fnsys.2014.00230
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