Nucleotide sequence of conjugative prophage Φ1207.3 (formerly Tn1207.3) carrying the mef(A)/msr(D) genes for efflux resistance to macrolides in Streptococcus pyogenes

Genetic element Φ1207.3 (formerly Tn1207.3) is a prophage of Streptococcus pyogenes which carries the macrolide efflux resistance genes mef(A)/msr(D) and is capable of conjugal transfer among streptococci. Complete nucleotide sequence showed that Φ1207.3 is 52,491 bp in length and contained 58 open re...

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Autores principales: Iannelli, Francesco, Santagati, Maria, Santoro, Francesco, Oggioni, Marco R., Stefani, Stefania, Pozzi, Gianni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260502/
https://www.ncbi.nlm.nih.gov/pubmed/25538698
http://dx.doi.org/10.3389/fmicb.2014.00687
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author Iannelli, Francesco
Santagati, Maria
Santoro, Francesco
Oggioni, Marco R.
Stefani, Stefania
Pozzi, Gianni
author_facet Iannelli, Francesco
Santagati, Maria
Santoro, Francesco
Oggioni, Marco R.
Stefani, Stefania
Pozzi, Gianni
author_sort Iannelli, Francesco
collection PubMed
description Genetic element Φ1207.3 (formerly Tn1207.3) is a prophage of Streptococcus pyogenes which carries the macrolide efflux resistance genes mef(A)/msr(D) and is capable of conjugal transfer among streptococci. Complete nucleotide sequence showed that Φ1207.3 is 52,491 bp in length and contained 58 open reading frames (ORFs). A manual homology-based annotation with functional prediction of the hypothetical gene product was possible only for 34 out of 58 ORFs. Φ1207.3 codes for two different C-methylation systems, several phage structural genes, a lysis cassette (composed by a holin and a peptidoglycan hydrolase), and three site-specific resolvases of the serine recombinase family.
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spelling pubmed-42605022014-12-23 Nucleotide sequence of conjugative prophage Φ1207.3 (formerly Tn1207.3) carrying the mef(A)/msr(D) genes for efflux resistance to macrolides in Streptococcus pyogenes Iannelli, Francesco Santagati, Maria Santoro, Francesco Oggioni, Marco R. Stefani, Stefania Pozzi, Gianni Front Microbiol Microbiology Genetic element Φ1207.3 (formerly Tn1207.3) is a prophage of Streptococcus pyogenes which carries the macrolide efflux resistance genes mef(A)/msr(D) and is capable of conjugal transfer among streptococci. Complete nucleotide sequence showed that Φ1207.3 is 52,491 bp in length and contained 58 open reading frames (ORFs). A manual homology-based annotation with functional prediction of the hypothetical gene product was possible only for 34 out of 58 ORFs. Φ1207.3 codes for two different C-methylation systems, several phage structural genes, a lysis cassette (composed by a holin and a peptidoglycan hydrolase), and three site-specific resolvases of the serine recombinase family. Frontiers Media S.A. 2014-12-09 /pmc/articles/PMC4260502/ /pubmed/25538698 http://dx.doi.org/10.3389/fmicb.2014.00687 Text en Copyright © 2014 Iannelli, Santagati, Santoro, Oggioni, Stefani and Pozzi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Iannelli, Francesco
Santagati, Maria
Santoro, Francesco
Oggioni, Marco R.
Stefani, Stefania
Pozzi, Gianni
Nucleotide sequence of conjugative prophage Φ1207.3 (formerly Tn1207.3) carrying the mef(A)/msr(D) genes for efflux resistance to macrolides in Streptococcus pyogenes
title Nucleotide sequence of conjugative prophage Φ1207.3 (formerly Tn1207.3) carrying the mef(A)/msr(D) genes for efflux resistance to macrolides in Streptococcus pyogenes
title_full Nucleotide sequence of conjugative prophage Φ1207.3 (formerly Tn1207.3) carrying the mef(A)/msr(D) genes for efflux resistance to macrolides in Streptococcus pyogenes
title_fullStr Nucleotide sequence of conjugative prophage Φ1207.3 (formerly Tn1207.3) carrying the mef(A)/msr(D) genes for efflux resistance to macrolides in Streptococcus pyogenes
title_full_unstemmed Nucleotide sequence of conjugative prophage Φ1207.3 (formerly Tn1207.3) carrying the mef(A)/msr(D) genes for efflux resistance to macrolides in Streptococcus pyogenes
title_short Nucleotide sequence of conjugative prophage Φ1207.3 (formerly Tn1207.3) carrying the mef(A)/msr(D) genes for efflux resistance to macrolides in Streptococcus pyogenes
title_sort nucleotide sequence of conjugative prophage φ1207.3 (formerly tn1207.3) carrying the mef(a)/msr(d) genes for efflux resistance to macrolides in streptococcus pyogenes
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260502/
https://www.ncbi.nlm.nih.gov/pubmed/25538698
http://dx.doi.org/10.3389/fmicb.2014.00687
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