Sequential Sonagashira and Larock Indole Synthesis Reactions in a General Strategy To Prepare Biologically Active β-Carboline-Containing Alkaloids

[Image: see text] A general synthetic approach to β-carboline-containing alkaloids was developed. Two consecutive palladium-mediated processes, a Sonagashira coupling and a Larock indole annulation reaction, are central to the method. The scope of the approach was investigated and found to be amenab...

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Autores principales: Pan, Xiaohong, Bannister, Thomas D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260633/
https://www.ncbi.nlm.nih.gov/pubmed/25393979
http://dx.doi.org/10.1021/ol5029783
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author Pan, Xiaohong
Bannister, Thomas D.
author_facet Pan, Xiaohong
Bannister, Thomas D.
author_sort Pan, Xiaohong
collection PubMed
description [Image: see text] A general synthetic approach to β-carboline-containing alkaloids was developed. Two consecutive palladium-mediated processes, a Sonagashira coupling and a Larock indole annulation reaction, are central to the method. The scope of the approach was investigated and found to be amenable for constructing a variety of biologically significant natural products and also for preparing substituted analogues for optimization and analysis of their biological properties.
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spelling pubmed-42606332015-11-13 Sequential Sonagashira and Larock Indole Synthesis Reactions in a General Strategy To Prepare Biologically Active β-Carboline-Containing Alkaloids Pan, Xiaohong Bannister, Thomas D. Org Lett [Image: see text] A general synthetic approach to β-carboline-containing alkaloids was developed. Two consecutive palladium-mediated processes, a Sonagashira coupling and a Larock indole annulation reaction, are central to the method. The scope of the approach was investigated and found to be amenable for constructing a variety of biologically significant natural products and also for preparing substituted analogues for optimization and analysis of their biological properties. American Chemical Society 2014-11-13 2014-12-05 /pmc/articles/PMC4260633/ /pubmed/25393979 http://dx.doi.org/10.1021/ol5029783 Text en Copyright © 2014 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Pan, Xiaohong
Bannister, Thomas D.
Sequential Sonagashira and Larock Indole Synthesis Reactions in a General Strategy To Prepare Biologically Active β-Carboline-Containing Alkaloids
title Sequential Sonagashira and Larock Indole Synthesis Reactions in a General Strategy To Prepare Biologically Active β-Carboline-Containing Alkaloids
title_full Sequential Sonagashira and Larock Indole Synthesis Reactions in a General Strategy To Prepare Biologically Active β-Carboline-Containing Alkaloids
title_fullStr Sequential Sonagashira and Larock Indole Synthesis Reactions in a General Strategy To Prepare Biologically Active β-Carboline-Containing Alkaloids
title_full_unstemmed Sequential Sonagashira and Larock Indole Synthesis Reactions in a General Strategy To Prepare Biologically Active β-Carboline-Containing Alkaloids
title_short Sequential Sonagashira and Larock Indole Synthesis Reactions in a General Strategy To Prepare Biologically Active β-Carboline-Containing Alkaloids
title_sort sequential sonagashira and larock indole synthesis reactions in a general strategy to prepare biologically active β-carboline-containing alkaloids
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260633/
https://www.ncbi.nlm.nih.gov/pubmed/25393979
http://dx.doi.org/10.1021/ol5029783
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