Copper-Catalyzed Oxidative Homo- and Cross-Coupling of Grignard Reagents Using Diaziridinone

[Image: see text] Transition-metal-catalyzed cross-coupling reactions are among the most powerful synthetic transformations. This paper describes an efficient copper-catalyzed homo- and cross-coupling of Grignard reagents with di-tert-butyldiaziridinone as oxidant under mild conditions, giving the c...

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Autores principales: Zhu, Yingguang, Xiong, Tao, Han, Wenyong, Shi, Yian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260645/
https://www.ncbi.nlm.nih.gov/pubmed/25420218
http://dx.doi.org/10.1021/ol5030103
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author Zhu, Yingguang
Xiong, Tao
Han, Wenyong
Shi, Yian
author_facet Zhu, Yingguang
Xiong, Tao
Han, Wenyong
Shi, Yian
author_sort Zhu, Yingguang
collection PubMed
description [Image: see text] Transition-metal-catalyzed cross-coupling reactions are among the most powerful synthetic transformations. This paper describes an efficient copper-catalyzed homo- and cross-coupling of Grignard reagents with di-tert-butyldiaziridinone as oxidant under mild conditions, giving the coupling products in good to excellent yields. The reaction process has a broad substrate scope and is also effective for the C(sp)–C(sp(3)) coupling.
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spelling pubmed-42606452015-11-24 Copper-Catalyzed Oxidative Homo- and Cross-Coupling of Grignard Reagents Using Diaziridinone Zhu, Yingguang Xiong, Tao Han, Wenyong Shi, Yian Org Lett [Image: see text] Transition-metal-catalyzed cross-coupling reactions are among the most powerful synthetic transformations. This paper describes an efficient copper-catalyzed homo- and cross-coupling of Grignard reagents with di-tert-butyldiaziridinone as oxidant under mild conditions, giving the coupling products in good to excellent yields. The reaction process has a broad substrate scope and is also effective for the C(sp)–C(sp(3)) coupling. American Chemical Society 2014-11-24 2014-12-05 /pmc/articles/PMC4260645/ /pubmed/25420218 http://dx.doi.org/10.1021/ol5030103 Text en Copyright © 2014 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Zhu, Yingguang
Xiong, Tao
Han, Wenyong
Shi, Yian
Copper-Catalyzed Oxidative Homo- and Cross-Coupling of Grignard Reagents Using Diaziridinone
title Copper-Catalyzed Oxidative Homo- and Cross-Coupling of Grignard Reagents Using Diaziridinone
title_full Copper-Catalyzed Oxidative Homo- and Cross-Coupling of Grignard Reagents Using Diaziridinone
title_fullStr Copper-Catalyzed Oxidative Homo- and Cross-Coupling of Grignard Reagents Using Diaziridinone
title_full_unstemmed Copper-Catalyzed Oxidative Homo- and Cross-Coupling of Grignard Reagents Using Diaziridinone
title_short Copper-Catalyzed Oxidative Homo- and Cross-Coupling of Grignard Reagents Using Diaziridinone
title_sort copper-catalyzed oxidative homo- and cross-coupling of grignard reagents using diaziridinone
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260645/
https://www.ncbi.nlm.nih.gov/pubmed/25420218
http://dx.doi.org/10.1021/ol5030103
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AT hanwenyong coppercatalyzedoxidativehomoandcrosscouplingofgrignardreagentsusingdiaziridinone
AT shiyian coppercatalyzedoxidativehomoandcrosscouplingofgrignardreagentsusingdiaziridinone

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