Cargando…

Enantioselective Synthesis of Spliceostatin E and Evaluation of Biological Activity

[Image: see text] An enantioselective total synthesis of spliceostatin E has been accomplished. The δ-lactone unit A was constructed from readily available (R)-glycidyl alcohol using a ring-closing olefin metathesis as the key reaction. A cross-metathesis of ring A containing δ-lactone and the funct...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ghosh, Arun K., Veitschegger, Anne M., Sheri, Venkata Reddy, Effenberger, Kerstin A., Prichard, Beth E., Jurica, Melissa S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260646/ https://www.ncbi.nlm.nih.gov/pubmed/25423085 http://dx.doi.org/10.1021/ol503127r

Ejemplares similares

Enantioselective Total Syntheses of FR901464 and Spliceostatin A and Evaluation of Splicing Activity of Key Derivatives
por: Ghosh, Arun K., et al.
Publicado: (2014)

Spliceostatin A inhibits spliceosome assembly subsequent to prespliceosome formation
por: Roybal, Gabriel A., et al.
Publicado: (2010)

Interchangeable SF3B1 inhibitors interfere with pre-mRNA splicing at multiple stages
por: Effenberger, Kerstin A., et al.
Publicado: (2016)

Total Synthesis of GEX1Q1, Assignment of C-5 Stereoconfiguration and Evaluation of Spliceosome Inhibitory Activity
por: Ghosh, Arun K., et al.
Publicado: (2014)

Syntheses of spliceostatins and thailanstatins: a review
por: Donaldson, William A
Publicado: (2020)

CCNE1 and E2F1 Partially Suppress G1 Phase Arrest Caused by Spliceostatin A Treatment
por: Kikuchi, Kei, et al.
Publicado: (2021)

Global analysis of pre-mRNA subcellular localization following splicing inhibition by spliceostatin A
por: Yoshimoto, Rei, et al.
Publicado: (2017)

Spliceostatin C, a component of a microbial bioherbicide, is a potent phytotoxin that inhibits the spliceosome
por: Bajsa-Hirschel, Joanna, et al.
Publicado: (2023)

Complete Genome Sequence of Soil Bacterium Burkholderia sp. Strain FERM BP-3421, a Producer of Spliceostatins
por: Kunakom, Sylvia, et al.
Publicado: (2023)

Breaking Up the C Complex Spliceosome Shows Stable Association of Proteins with the Lariat Intron Intermediate
por: Coltri, Patricia, et al.
Publicado: (2011)

Enantioselective Synthesis of (−)-Acetylapoaranotin
por: Wang, Haoxuan, et al.
Publicado: (2017)

Synthesis and Evaluation of the (S)-BINAM Derivatives as Fluorescent Enantioselective Detectors
por: Shaferov, Alexander V., et al.
Publicado: (2020)

Enantioselective synthesis : natural products from chiral terpenes /
por: Ho, Tse-Lok
Publicado: (1992)

The enantioselective synthesis of (S)-(+)-mianserin and (S)-(+)-epinastine
por: Roszkowski, Piotr, et al.
Publicado: (2015)

Enantioselective Total Synthesis of (+)-Heilonine
por: Cassaidy, Kyle J., et al.
Publicado: (2021)

Biocatalytic Enantioselective Synthesis of Atropisomers
por: Watts, Olivia F. B., et al.
Publicado: (2022)

Enantioselective Synthesis and in Vivo Evaluation of Regioisomeric Analogues of the Antimalarial Arterolane
por: Blank, Brian R., et al.
Publicado: (2017)

A Modular, Enantioselective Synthesis of Resolvins D3, E1, and Hybrids
por: Urbitsch, Felix, et al.
Publicado: (2020)

Scalable, enantioselective taxane total synthesis
por: Mendoza, Abraham, et al.
Publicado: (2011)

Enantioselective total synthesis of (R)-(−)-complanine
por: Kamanos, Krystal A D, et al.
Publicado: (2012)

Enantioselective Total Synthesis of (+)-Lyngbyabellin M
por: Pirovani, Rodrigo V., et al.
Publicado: (2015)

Applications of Bolm’s Ligand in Enantioselective Synthesis
por: Bednářová, Eva, et al.
Publicado: (2020)

Enantioselective Total Synthesis of (+)‐Garsubellin A
por: Jang, Dongseok, et al.
Publicado: (2021)

The enantioselective total synthesis of laurendecumallene B
por: Taylor, Cooper A., et al.
Publicado: (2020)

Enantioselective Synthesis of Fluorinated Indolizidinone Derivatives
por: Escolano, Marcos, et al.
Publicado: (2023)

Catalytic Enantioselective 1,3-Dipolar Cycloadditions of Azomethine Ylides for Biology-Oriented Synthesis
por: Narayan, Rishikesh, et al.
Publicado: (2014)

A New Organocatalytic Desymmetrization Reaction Enables the Enantioselective Total Synthesis of Madangamine E
por: Shiomi, Shinya, et al.
Publicado: (2022)

Highly enantioselective catalytic synthesis of chiral pyridines
por: Jumde, Ravindra P., et al.
Publicado: (2017)

Enantioselective total synthesis of the unnatural enantiomer of quinine
por: Shiomi, Shinya, et al.
Publicado: (2019)

Enantioselective Synthesis, Enantiomeric Separations and Chiral Recognition
por: Tiritan, Maria Elizabeth, et al.
Publicado: (2020)

Enantioselective Copper-Catalyzed Synthesis of Trifluoromethyl-Cyclopropylboronates
por: Altarejos, Julia, et al.
Publicado: (2021)

Short, enantioselective, gram-scale synthesis of (−)-zephyranthine
por: Zhao, Yuxiang, et al.
Publicado: (2021)

Enantioselective total synthesis of (−)-myrifabral A and B
por: Fulton, Tyler J., et al.
Publicado: (2020)

Synthesis of (+)-ribostamycin by catalytic, enantioselective hydroamination of benzene
por: Ungarean, Chad N., et al.
Publicado: (2022)

Studies on the Enantioselective Synthesis of E-Ethylidene-bearing Spiro[indolizidine-1,3′-oxindole] Alkaloids
por: Yayik, Nihan, et al.
Publicado: (2021)

U2 snRNA structure is influenced by SF3A and SF3B proteins but not by SF3B inhibitors
por: Urabe, Veronica K., et al.
Publicado: (2021)

The effect of body size evolution and ecology on encephalization in cave bears and extant relatives
por: Veitschegger, Kristof
Publicado: (2017)

A model for DHX15 mediated disassembly of A-complex spliceosomes
por: Maul-Newby, Hannah M., et al.
Publicado: (2022)

Organocatalysis in Synthesis: L-Proline as an Enantioselective Catalyst in the Synthesis of Pyrans and Thiopyrans
por: Elnagdi, Noha M. Hilmy, et al.
Publicado: (2012)

Copper-catalyzed enantioselective stereodivergent synthesis of amino alcohols
por: Shi, Shi-Liang, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_eaqu19dhtqcc52g4n1u5npp5fb