Cancer cell death induced by novel small molecules degrading the TACC3 protein via the ubiquitin–proteasome pathway

The selective degradation of target proteins with small molecules is a novel approach to the treatment of various diseases, including cancer. We have developed a protein knockdown system with a series of hybrid small compounds that induce the selective degradation of target proteins via the ubiquiti...

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Detalles Bibliográficos
Autores principales: Ohoka, N, Nagai, K, Hattori, T, Okuhira, K, Shibata, N, Cho, N, Naito, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260729/
https://www.ncbi.nlm.nih.gov/pubmed/25375378
http://dx.doi.org/10.1038/cddis.2014.471

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260729/
https://www.ncbi.nlm.nih.gov/pubmed/25375378
http://dx.doi.org/10.1038/cddis.2014.471

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