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Cancer cell death induced by novel small molecules degrading the TACC3 protein via the ubiquitin–proteasome pathway
The selective degradation of target proteins with small molecules is a novel approach to the treatment of various diseases, including cancer. We have developed a protein knockdown system with a series of hybrid small compounds that induce the selective degradation of target proteins via the ubiquiti...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260729/ https://www.ncbi.nlm.nih.gov/pubmed/25375378 http://dx.doi.org/10.1038/cddis.2014.471 |