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Zoledronic acid induces apoptosis and S-phase arrest in mesothelioma through inhibiting Rab family proteins and topoisomerase II actions

Zoledronic acid (ZOL), a nitrogen-containing bisphosphonate, produced anti-tumor effects through apoptosis induction or S-phase arrest depending on human mesothelioma cells tested. An addition of isoprenoid, geranylgeraniol but not farnesol, negated these ZOL-induced effects, indicating that the ZOL...

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Detalles Bibliográficos
Autores principales:	Okamoto, S, Jiang, Y, Kawamura, K, Shingyoji, M, Tada, Y, Sekine, I, Takiguchi, Y, Tatsumi, K, Kobayashi, H, Shimada, H, Hiroshima, K, Tagawa, M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260733/ https://www.ncbi.nlm.nih.gov/pubmed/25393473 http://dx.doi.org/10.1038/cddis.2014.475

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