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SHMT1 knockdown induces apoptosis in lung cancer cells by causing uracil misincorporation

Reprogramming of cellular metabolism towards de novo serine production fuels the growth of cancer cells, providing essential precursors such as amino acids and nucleotides and controlling the antioxidant and methylation capacities of the cell. The enzyme serine hydroxymethyltransferase (SHMT) has a...

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Detalles Bibliográficos
Autores principales:	Paone, A, Marani, M, Fiascarelli, A, Rinaldo, S, Giardina, G, Contestabile, R, Paiardini, A, Cutruzzolà, F
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260740/ https://www.ncbi.nlm.nih.gov/pubmed/25412303 http://dx.doi.org/10.1038/cddis.2014.482

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