SAP97-mediated ADAM10 trafficking from Golgi outposts depends on PKC phosphorylation

A disintegrin and metalloproteinase 10 (ADAM10) is the major α-secretase that catalyzes the amyloid precursor protein (APP) ectodomain shedding in the brain and prevents amyloid formation. Its activity depends on correct intracellular trafficking and on synaptic membrane insertion. Here, we describe...

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Detalles Bibliográficos
Autores principales: Saraceno, C, Marcello, E, Di Marino, D, Borroni, B, Claeysen, S, Perroy, J, Padovani, A, Tramontano, A, Gardoni, F, Di Luca, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260750/
https://www.ncbi.nlm.nih.gov/pubmed/25429624
http://dx.doi.org/10.1038/cddis.2014.492

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