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Combination simvastatin and metformin induces G1-phase cell cycle arrest and Ripk1- and Ripk3-dependent necrosis in C4-2B osseous metastatic castration-resistant prostate cancer cells

Castration-resistant prostate cancer (CRPC) cells acquire resistance to chemotherapy and apoptosis, in part, due to enhanced aerobic glycolysis and biomass production, known as the Warburg effect. We previously demonstrated that combination simvastatin (SIM) and metformin (MET) ameliorates critical...

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Detalles Bibliográficos
Autores principales:	Babcook, M A, Sramkoski, R M, Fujioka, H, Daneshgari, F, Almasan, A, Shukla, S, Nanavaty, R R, Gupta, S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260755/ https://www.ncbi.nlm.nih.gov/pubmed/25412314 http://dx.doi.org/10.1038/cddis.2014.500

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