Inhibition of phosphodiesterase 5 reduces bone mass by suppression of canonical Wnt signaling

Inhibitors of phosphodiesterase 5 (PDE5) are widely used to treat erectile dysfunction and pulmonary hypertension in clinics. PDE5, cyclic guanosine monophosphate (cGMP), and protein kinase G (PKG) are important components of the non-canonical Wnt signaling. This study aimed to investigate the effec...

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Detalles Bibliográficos
Autores principales: Gong, Y, Xu, C Y, Wang, J R, Hu, X H, Hong, D, Ji, X, Shi, W, Chen, H X, Wang, H B, Wu, X M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260761/
https://www.ncbi.nlm.nih.gov/pubmed/25429621
http://dx.doi.org/10.1038/cddis.2014.510

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