Cargando…

The Maternal Serological Response to Intrauterine Ureaplasma sp. Infection and Prediction of Risk of Pre-Term Birth

Pre-term birth (PTB) associated with intrauterine infection and inflammation (IUI) is the major cause of early PTB less than 32 weeks of gestation. Ureaplasma spp. are common commensals of the urogenital tract in pregnancy and are the most commonly identified microorganisms in amniotic fluid of pre-...

Descripción completa

Detalles Bibliográficos
Autores principales: Ireland, Demelza J., Keelan, Jeffrey A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260765/
https://www.ncbi.nlm.nih.gov/pubmed/25538708
http://dx.doi.org/10.3389/fimmu.2014.00624
_version_ 1782348220555329536
author Ireland, Demelza J.
Keelan, Jeffrey A.
author_facet Ireland, Demelza J.
Keelan, Jeffrey A.
author_sort Ireland, Demelza J.
collection PubMed
description Pre-term birth (PTB) associated with intrauterine infection and inflammation (IUI) is the major cause of early PTB less than 32 weeks of gestation. Ureaplasma spp. are common commensals of the urogenital tract in pregnancy and are the most commonly identified microorganisms in amniotic fluid of pre-term pregnancies. While we have an understanding of the causal relationship between intra-amniotic infection, inflammation and PTB, we are still unable to explain why vaginal Ureaplasma sp. colonization is tolerated in some women but causes PTB in others. It is now known that placental tissues are frequently colonized by bacteria even in apparently healthy pregnancies delivered at term; usually this occurs in the absence of a significant local inflammatory response. It appears, therefore, that the site, nature, and magnitude of the immune response to infiltrating microorganisms are key in determining pregnancy outcome. Some evidence exists that the maternal serological response to Ureaplasma sp. colonization may be predictive of adverse pregnancy outcome, although issues such as the importance of virulence factors (serovars) and the timing, magnitude, and functional consequences of the immune response await clarification. This mini-review discusses the evidence linking the maternal immune response to risk of PTB and the potential applications of maternal serological analysis for predicting obstetric outcome.
format Online
Article
Text
id pubmed-4260765
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-42607652014-12-23 The Maternal Serological Response to Intrauterine Ureaplasma sp. Infection and Prediction of Risk of Pre-Term Birth Ireland, Demelza J. Keelan, Jeffrey A. Front Immunol Immunology Pre-term birth (PTB) associated with intrauterine infection and inflammation (IUI) is the major cause of early PTB less than 32 weeks of gestation. Ureaplasma spp. are common commensals of the urogenital tract in pregnancy and are the most commonly identified microorganisms in amniotic fluid of pre-term pregnancies. While we have an understanding of the causal relationship between intra-amniotic infection, inflammation and PTB, we are still unable to explain why vaginal Ureaplasma sp. colonization is tolerated in some women but causes PTB in others. It is now known that placental tissues are frequently colonized by bacteria even in apparently healthy pregnancies delivered at term; usually this occurs in the absence of a significant local inflammatory response. It appears, therefore, that the site, nature, and magnitude of the immune response to infiltrating microorganisms are key in determining pregnancy outcome. Some evidence exists that the maternal serological response to Ureaplasma sp. colonization may be predictive of adverse pregnancy outcome, although issues such as the importance of virulence factors (serovars) and the timing, magnitude, and functional consequences of the immune response await clarification. This mini-review discusses the evidence linking the maternal immune response to risk of PTB and the potential applications of maternal serological analysis for predicting obstetric outcome. Frontiers Media S.A. 2014-12-09 /pmc/articles/PMC4260765/ /pubmed/25538708 http://dx.doi.org/10.3389/fimmu.2014.00624 Text en Copyright © 2014 Ireland and Keelan. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Ireland, Demelza J.
Keelan, Jeffrey A.
The Maternal Serological Response to Intrauterine Ureaplasma sp. Infection and Prediction of Risk of Pre-Term Birth
title The Maternal Serological Response to Intrauterine Ureaplasma sp. Infection and Prediction of Risk of Pre-Term Birth
title_full The Maternal Serological Response to Intrauterine Ureaplasma sp. Infection and Prediction of Risk of Pre-Term Birth
title_fullStr The Maternal Serological Response to Intrauterine Ureaplasma sp. Infection and Prediction of Risk of Pre-Term Birth
title_full_unstemmed The Maternal Serological Response to Intrauterine Ureaplasma sp. Infection and Prediction of Risk of Pre-Term Birth
title_short The Maternal Serological Response to Intrauterine Ureaplasma sp. Infection and Prediction of Risk of Pre-Term Birth
title_sort maternal serological response to intrauterine ureaplasma sp. infection and prediction of risk of pre-term birth
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260765/
https://www.ncbi.nlm.nih.gov/pubmed/25538708
http://dx.doi.org/10.3389/fimmu.2014.00624
work_keys_str_mv AT irelanddemelzaj thematernalserologicalresponsetointrauterineureaplasmaspinfectionandpredictionofriskofpretermbirth
AT keelanjeffreya thematernalserologicalresponsetointrauterineureaplasmaspinfectionandpredictionofriskofpretermbirth
AT irelanddemelzaj maternalserologicalresponsetointrauterineureaplasmaspinfectionandpredictionofriskofpretermbirth
AT keelanjeffreya maternalserologicalresponsetointrauterineureaplasmaspinfectionandpredictionofriskofpretermbirth