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Receptor for Advanced Glycation End Products - Membrane Type1 Matrix Metalloproteinase Axis Regulates Tissue Factor Expression via RhoA and Rac1 Activation in High-Mobility Group Box-1 Stimulated Endothelial Cells

BACKGROUND: Atherosclerosis is understood to be a blood vessel inflammation. High-mobility group box-1 (HMGB-1) plays a key role in the systemic inflammation. Tissue factor (TF) is known to lead to inflammation which promotes thrombus formation. Membrane type1 matrix metalloprotease (MT1-MMP) associ...

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Detalles Bibliográficos
Autores principales:	Sugimoto, Koichi, Ohkawara, Hiroshi, Nakamura, Yuichi, Takuwa, Yoh, Ishibashi, Toshiyuki, Takeishi, Yasuchika
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260861/ https://www.ncbi.nlm.nih.gov/pubmed/25490770 http://dx.doi.org/10.1371/journal.pone.0114429

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