CRISPR-Cas9-Based Knockout of the Prion Protein and Its Effect on the Proteome

The molecular function of the cellular prion protein (PrP(C)) and the mechanism by which it may contribute to neurotoxicity in prion diseases and Alzheimer's disease are only partially understood. Mouse neuroblastoma Neuro2a cells and, more recently, C2C12 myocytes and myotubes have emerged as...

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Detalles Bibliográficos
Autores principales: Mehrabian, Mohadeseh, Brethour, Dylan, MacIsaac, Sarah, Kim, Jin Kyu, Gunawardana, C . Geeth, Wang, Hansen, Schmitt-Ulms, Gerold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260877/
https://www.ncbi.nlm.nih.gov/pubmed/25490046
http://dx.doi.org/10.1371/journal.pone.0114594

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260877/
https://www.ncbi.nlm.nih.gov/pubmed/25490046
http://dx.doi.org/10.1371/journal.pone.0114594

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