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Mimulone-Induced Autophagy through p53-Mediated AMPK/mTOR Pathway Increases Caspase-Mediated Apoptotic Cell Death in A549 Human Lung Cancer Cells

Anticancer properties and mechanisms of mimulone (MML), C-geranylflavonoid isolated from the Paulownia tomentosa fruits, were firstly elucidated in this study. MML prevented cell proliferation in a dose- and time-dependent way and triggered apoptosis through the extrinsic pathway in A549 human lung...

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Detalles Bibliográficos
Autores principales:	An, Hyun-Kyu, Kim, Kyoung-Sook, Lee, Ji-Won, Park, Mi-Hyun, Moon, Hyung-In, Park, Shin-Ji, Baik, Ji-Sue, Kim, Cheorl-Ho, Lee, Young-Choon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260910/ https://www.ncbi.nlm.nih.gov/pubmed/25490748 http://dx.doi.org/10.1371/journal.pone.0114607

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