Cargando…

Coronavirus non-structural protein 16: Evasion, attenuation, and possible treatments

The recent emergence of Middle East Respiratory Syndrome Coronavirus (MERS-CoV), nearly a decade after the Severe Acute Respiratory Syndrome (SARS) CoV, highlights the importance of understanding and developing therapeutic treatment for current and emergent CoVs. This manuscript explores the role of...

Descripción completa

Detalles Bibliográficos
Autores principales: Menachery, Vineet D., Debbink, Kari, Baric, Ralph S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier B.V. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260984/
https://www.ncbi.nlm.nih.gov/pubmed/25278144
http://dx.doi.org/10.1016/j.virusres.2014.09.009
_version_ 1782348254899339264
author Menachery, Vineet D.
Debbink, Kari
Baric, Ralph S.
author_facet Menachery, Vineet D.
Debbink, Kari
Baric, Ralph S.
author_sort Menachery, Vineet D.
collection PubMed
description The recent emergence of Middle East Respiratory Syndrome Coronavirus (MERS-CoV), nearly a decade after the Severe Acute Respiratory Syndrome (SARS) CoV, highlights the importance of understanding and developing therapeutic treatment for current and emergent CoVs. This manuscript explores the role of NSP16, a 2′O-methyl-transferase (2′O-MTase), in CoV infection and the host immune response. The review highlights conserved motifs, required interaction partners, as well as the attenuation of NSP16 mutants, and restoration of these mutants in specific immune knockouts. Importantly, the work also identifies a number of approaches to exploit this understanding for therapeutic treatment and the data clearly illustrate the importance of NSP16 2′O-MTase activity for CoV infection and pathogenesis.
format Online
Article
Text
id pubmed-4260984
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Published by Elsevier B.V.
record_format MEDLINE/PubMed
spelling pubmed-42609842015-12-19 Coronavirus non-structural protein 16: Evasion, attenuation, and possible treatments Menachery, Vineet D. Debbink, Kari Baric, Ralph S. Virus Res Article The recent emergence of Middle East Respiratory Syndrome Coronavirus (MERS-CoV), nearly a decade after the Severe Acute Respiratory Syndrome (SARS) CoV, highlights the importance of understanding and developing therapeutic treatment for current and emergent CoVs. This manuscript explores the role of NSP16, a 2′O-methyl-transferase (2′O-MTase), in CoV infection and the host immune response. The review highlights conserved motifs, required interaction partners, as well as the attenuation of NSP16 mutants, and restoration of these mutants in specific immune knockouts. Importantly, the work also identifies a number of approaches to exploit this understanding for therapeutic treatment and the data clearly illustrate the importance of NSP16 2′O-MTase activity for CoV infection and pathogenesis. Published by Elsevier B.V. 2014-12-19 2014-09-30 /pmc/articles/PMC4260984/ /pubmed/25278144 http://dx.doi.org/10.1016/j.virusres.2014.09.009 Text en Copyright © 2014 Published by Elsevier B.V. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Menachery, Vineet D.
Debbink, Kari
Baric, Ralph S.
Coronavirus non-structural protein 16: Evasion, attenuation, and possible treatments
title Coronavirus non-structural protein 16: Evasion, attenuation, and possible treatments
title_full Coronavirus non-structural protein 16: Evasion, attenuation, and possible treatments
title_fullStr Coronavirus non-structural protein 16: Evasion, attenuation, and possible treatments
title_full_unstemmed Coronavirus non-structural protein 16: Evasion, attenuation, and possible treatments
title_short Coronavirus non-structural protein 16: Evasion, attenuation, and possible treatments
title_sort coronavirus non-structural protein 16: evasion, attenuation, and possible treatments
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260984/
https://www.ncbi.nlm.nih.gov/pubmed/25278144
http://dx.doi.org/10.1016/j.virusres.2014.09.009
work_keys_str_mv AT menacheryvineetd coronavirusnonstructuralprotein16evasionattenuationandpossibletreatments
AT debbinkkari coronavirusnonstructuralprotein16evasionattenuationandpossibletreatments
AT baricralphs coronavirusnonstructuralprotein16evasionattenuationandpossibletreatments