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SIRT1 Deacetylates TopBP1 and Modulates Intra-S-Phase Checkpoint and DNA Replication Origin Firing

SIRT1, the mammalian homolog of yeast Sir2, is a founding member of a family of 7 protein and histone deacetylases that are involved in numerous biological functions. Previous studies revealed that SIRT1 deficiency results in genome instability, which eventually leads to cancer formation, yet the un...

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Detalles Bibliográficos
Autores principales:	Wang, Rui-Hong, Lahusen, Tyler J., Chen, Qiang, Xu, Xiaoling, Jenkins, Lisa M. Miller, Leo, Elisabetta, Fu, Haiqing, Aladjem, Mirit, Pommier, Yves, Appella, Ettore, Deng, Chu-Xia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2014
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4261203/ https://www.ncbi.nlm.nih.gov/pubmed/25516717 http://dx.doi.org/10.7150/ijbs.11066

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