Cargando…
Hypochlorous acid via peroxynitrite activates protein kinase Cθ and insulin resistance in adipocytes
We recently reported that genetic deletion of myeloperoxidase (MPO) alleviates obesity-related insulin resistance in mice in vivo. How MPO impairs insulin sensitivity in adipocytes is poorly characterized. As hypochlorous acid (HOCl) is a principal oxidant product generated by MPO, we evaluated the...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Bioscientifica Ltd
2015
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4261204/ https://www.ncbi.nlm.nih.gov/pubmed/25381390 http://dx.doi.org/10.1530/JME-14-0213 |