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Hypochlorous acid via peroxynitrite activates protein kinase Cθ and insulin resistance in adipocytes

We recently reported that genetic deletion of myeloperoxidase (MPO) alleviates obesity-related insulin resistance in mice in vivo. How MPO impairs insulin sensitivity in adipocytes is poorly characterized. As hypochlorous acid (HOCl) is a principal oxidant product generated by MPO, we evaluated the...

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Detalles Bibliográficos
Autores principales:	Zhou, Jun, Wang, Qilong, Ding, Ye, Zou, Ming-Hui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bioscientifica Ltd 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4261204/ https://www.ncbi.nlm.nih.gov/pubmed/25381390 http://dx.doi.org/10.1530/JME-14-0213

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