Cargando…

Deficient hippocampal insulin signaling and augmented Tau phosphorylation is related to obesity- and age-induced peripheral insulin resistance: a study in Zucker rats

BACKGROUND: Insulin signaling and Tau protein phosphorylation in the hippocampi of young and old obese Zucker fa/fa rats and their lean controls were assessed to determine whether obesity-induced peripheral insulin resistance and aging are risk factors for central insulin resistance and whether cent...

Descripción completa

Detalles Bibliográficos
Autores principales:	Špolcová, Andrea, Mikulášková, Barbora, Kršková, Katarína, Gajdošechová, Lucia, Zórad, Štefan, Olszanecki, Rafał, Suski, Maciej, Bujak-Giżycka, Beata, Železná, Blanka, Maletínská, Lenka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4261609/ https://www.ncbi.nlm.nih.gov/pubmed/25257559 http://dx.doi.org/10.1186/1471-2202-15-111

Ejemplares similares

Insulin-Regulated Aminopeptidase Inhibition Ameliorates Metabolism in Obese Zucker Rats
por: Krskova, Katarina, et al.
Publicado: (2020)

AVE0991, a Nonpeptide Angiotensin 1-7 Receptor Agonist, Improves Glucose Metabolism in the Skeletal Muscle of Obese Zucker Rats: Possible Involvement of Prooxidant/Antioxidant Mechanisms
por: Dobrocsyova, Viktoria, et al.
Publicado: (2020)

Aging and high-fat diet feeding lead to peripheral insulin resistance and sex-dependent changes in brain of mouse model of tau pathology THY-Tau22
por: Kacířová, Miroslava, et al.
Publicado: (2021)

Lipidized prolactin-releasing peptide improved glucose tolerance in metabolic syndrome: Koletsky and spontaneously hypertensive rat study
por: Mikulášková, Barbora, et al.
Publicado: (2018)

Impact of novel palmitoylated prolactin-releasing peptide analogs on metabolic changes in mice with diet-induced obesity
por: Pražienková, Veronika, et al.
Publicado: (2017)

Metabolomic Study of Aging in fa/fa Rats: Multiplatform Urine and Serum Analysis
por: Pelantová, Helena, et al.
Publicado: (2023)

Diminazene Aceturate Stabilizes Atherosclerotic Plaque and Attenuates Hepatic Steatosis in apoE-Knockout Mice by Influencing Macrophages Polarization and Taurine Biosynthesis
por: Stachowicz, Aneta, et al.
Publicado: (2021)

Cellular Signaling and Anti-Apoptotic Effects of Prolactin-Releasing Peptide and Its Analog on SH-SY5Y Cells
por: Zmeškalová, Anna, et al.
Publicado: (2020)

Palmitoylation of Prolactin-Releasing Peptide Increased Affinity for and Activation of the GPR10, NPFF-R2 and NPFF-R1 Receptors: In Vitro Study
por: Karnošová, Alena, et al.
Publicado: (2021)

NPFFR2-deficient mice fed a high-fat diet develop strong intolerance to glucose
por: Karnošová, Alena, et al.
Publicado: (2023)

Lipidized Prolactin-Releasing Peptide as a New Potential Tool to Treat Obesity and Type 2 Diabetes Mellitus: Preclinical Studies in Rodent Models
por: Mráziková, Lucia, et al.
Publicado: (2021)

Palmitoylated prolactin-releasing peptide treatment had neuroprotective but not anti-obesity effect in fa/fa rats with leptin signaling disturbances
por: Mráziková, Lucia, et al.
Publicado: (2022)

Feeding High-Fat Diet Accelerates Development of Peripheral and Central Insulin Resistance and Inflammation and Worsens AD-like Pathology in APP/PS1 Mice
por: Mengr, Anna, et al.
Publicado: (2023)

Synergistic effect of CART (cocaine- and amphetamine-regulated transcript) peptide and cholecystokinin on food intake regulation in lean mice
por: Maletínská, Lenka, et al.
Publicado: (2008)

Age-related metabolic and neurodegenerative changes in SAMP8 mice
por: Pačesová, Andrea, et al.
Publicado: (2022)

A fatal case of poisoning with a cathinone derivative: α-PiHP and its postmortem distribution in body fluids and organ tissues
por: Wachholz, Paulina, et al.
Publicado: (2023)

Modulation of Adipogenesis and Oxidative Status by Quercetin and Ochratoxin A: Positive or Negative Impact on Rat Adipocyte Metabolism?
por: Dobrocsyova, Viktoria, et al.
Publicado: (2019)

Pulmonary arterial dysfunction in insulin resistant obese Zucker rats
por: Moral-Sanz, Javier, et al.
Publicado: (2011)

Lipidized PrRP Analog Exhibits Strong Anti-Obesity and Antidiabetic Properties in Old WKY Rats with Obesity and Glucose Intolerance
por: Mráziková, Lucia, et al.
Publicado: (2023)

Effect of Feeding Status on Adjuvant Arthritis Severity, Cachexia, and Insulin Sensitivity in Male Lewis Rats
por: Stofkova, Andrea, et al.
Publicado: (2010)

Exogenous Angiotensin I Metabolism in Aorta Isolated from Streptozotocin Treated Diabetic Rats
por: Wołkow, P. P., et al.
Publicado: (2016)

Pathophysiology of NAFLD and NASH in Experimental Models: The Role of Food Intake Regulating Peptides
por: Kořínková, L., et al.
Publicado: (2020)

Structural and Functional Study of the GlnB22-Insulin Mutant Responsible for Maturity-Onset Diabetes of the Young
por: Křížková, Květoslava, et al.
Publicado: (2014)

C-Peptide-Based Assessment of Insulin Secretion in the Zucker Fatty Rat: A Modelistic Study
por: Di Nardo, Francesco, et al.
Publicado: (2015)

Hepatic lesions induced by feeding Western diets to Zucker fatty rats, an insulin-resistant model
por: Saito, Tomoyuki, et al.
Publicado: (2018)

Amelioration of Hippocampal Insulin Resistance Reduces Tau Hyperphosphorylation and Cognitive Decline Induced by Isoflurane in Mice
por: Peng, Liangyu, et al.
Publicado: (2021)

Insulin dysfunction and Tau pathology
por: El Khoury, Noura B., et al.
Publicado: (2014)

Remarkable features of ovarian morphology and reproductive hormones in insulin-resistant Zucker fatty (fa/fa) rats
por: Honnma, Hiroyuki, et al.
Publicado: (2010)

Pioglitazone is effective for multiple phenotyepes of the Zucker fa/fa rat with polycystc ovary morphology and insulin resistance
por: Morishita, Miyuki, et al.
Publicado: (2018)

Liraglutide treatment improves the coronary microcirculation in insulin resistant Zucker obese rats on a high salt diet
por: Sukumaran, Vijayakumar, et al.
Publicado: (2020)

Increased monoamine oxidase activity and imidazoline binding sites in insulin-resistant adipocytes from obese Zucker rats
por: Carpéné, Christian, et al.
Publicado: (2022)

Reduced Tyrosine and Serine-632 Phosphorylation of Insulin Receptor Substrate-1 in the Gastrocnemius Muscle of Obese Zucker Rat
por: Ola, Mohammad Shamsul
Publicado: (2022)

Tau deletion promotes brain insulin resistance
por: Marciniak, Elodie, et al.
Publicado: (2017)

Vitamin A and Feeding Statuses Modulate the Insulin-Regulated Gene Expression in Zucker Lean and Fatty Primary Rat Hepatocytes
por: Chen, Wei, et al.
Publicado: (2014)

Therapeutic Effect of Vagus Nerve Stimulation on Depressive-Like Behavior, Hyperglycemia and Insulin Receptor Expression in Zucker Fatty Rats
por: Li, Shaoyuan, et al.
Publicado: (2014)

Optimization of quantitative proteomic analysis of clots generated from plasma of patients with venous thromboembolism
por: Stachowicz, Aneta, et al.
Publicado: (2017)

Proteomic Analysis of Mitochondria-Enriched Fraction Isolated from the Frontal Cortex and Hippocampus of Apolipoprotein E Knockout Mice Treated with Alda-1, an Activator of Mitochondrial Aldehyde Dehydrogenase (ALDH2)
por: Stachowicz, Aneta, et al.
Publicado: (2017)

Structural Perspectives of Insulin Receptor Isoform-Selective Insulin Analogs
por: Jiráček, Jiří, et al.
Publicado: (2017)

Hydroxypropyl methylcellulose, a viscous soluble fiber, reduces insulin resistance and decreases fatty liver in Zucker Diabetic Fatty rats
por: Brockman, David A, et al.
Publicado: (2012)

High-fat diet impairs spatial memory and hippocampal intrinsic excitability and sex-dependently alters circulating insulin and hippocampal insulin sensitivity
por: Underwood, Erica L., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_io3rpp1acd5rnpckv0ba2onp3p